◀ Back to EDN1
EDN1 — EDNRB
Pathways - manually collected, often from reviews:
-
BioCarta ß-arrestins in gpcr desensitization:
ligand/GPCR complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3)
→
G-protein Receptor (HTR2C/ADRA1B/AGTR2/CHRM1/CCR5/PTGER1/P2RY2/CCR3/EDNRB/EDNRA/CXCR4/FPR1/ADRB2)
(degradation, collaborate)
-
BioCarta role of egf receptor transactivation by gpcrs in cardiac hypertrophy:
Endothelin 1/Endothelin receptor complex (EDN1-EDNRB_EDNRA)
→
Endothelin receptor (EDNRB/EDNRA)
(modification, collaborate)
-
BioCarta role of egf receptor transactivation by gpcrs in cardiac hypertrophy:
Endothelin 1/Endothelin receptor complex (EDN1-EDNRB_EDNRA)
→
Endothelin 1 (EDN1)
(modification, collaborate)
-
BioCarta role of egf receptor transactivation by gpcrs in cardiac hypertrophy:
Endothelin receptor (EDNRB/EDNRA)
→
Endothelin 1 (EDN1)
(modification, collaborate)
-
BioCarta role of egf receptor transactivation by gpcrs in cardiac hypertrophy:
Endothelin 1/Endothelin receptor complex (EDN1-EDNRB_EDNRA)
→
PLC-gamma (PLCG1)
(modification, activates)
-
KEGG Melanogenesis:
EDN1
→
EDNRB
(protein-protein, activation)
-
NCI Pathway Database Endothelins:
Gai/GDP complex (GNAI2_GNAI3_GNAO1_GNAO1_GNAZ_GNAI1)
→
ETB receptor/Endothelin-1/Gi/GTP complex (EDNRB-EDN1-GNAI2_GNAI3_GNAO1_GNAO1_GNAZ_GNAI1)
(modification, collaborate)
Aramori et al., J Biol Chem 1992
-
NCI Pathway Database Endothelins:
Gai/GDP complex (GNAI2_GNAI3_GNAO1_GNAO1_GNAZ_GNAI1)
→
ETB receptor/Endothelin-1 complex (EDNRB-EDN1)
(modification, collaborate)
Aramori et al., J Biol Chem 1992
-
NCI Pathway Database Endothelins:
None
→
ETB receptor/Endothelin-1/Gi/GTP complex (EDNRB-EDN1-GNAI2_GNAI3_GNAO1_GNAO1_GNAZ_GNAI1)
(modification, collaborate)
Aramori et al., J Biol Chem 1992
-
NCI Pathway Database Endothelins:
None
→
ETB receptor/Endothelin-1 complex (EDNRB-EDN1)
(modification, collaborate)
Aramori et al., J Biol Chem 1992
-
NCI Pathway Database Endothelins:
ETB receptor/Endothelin-1/Gi/GTP complex (EDNRB-EDN1-GNAI2_GNAI3_GNAO1_GNAO1_GNAZ_GNAI1)
→
ETB receptor/Endothelin-1 complex (EDNRB-EDN1)
(modification, collaborate)
Aramori et al., J Biol Chem 1992
-
NCI Pathway Database Endothelins:
ETB receptor/Endothelin-1/Gi/GTP complex (EDNRB-EDN1-GNAI2_GNAI3_GNAO1_GNAO1_GNAZ_GNAI1)
→
None
(modification, collaborate)
Aramori et al., J Biol Chem 1992
-
NCI Pathway Database Endothelins:
ETB receptor/Endothelin-1 complex (EDNRB-EDN1)
→
None
(modification, collaborate)
Aramori et al., J Biol Chem 1992
-
NCI Pathway Database Endothelins:
None
→
ETB receptor/Endothelin-1 complex (EDNRB-EDN1)
(modification, activates)
Chu et al., J Clin Invest 1996*
Evidence: mutant phenotype, other species
-
NCI Pathway Database Endothelins:
None
→
ETB receptor/Endothelin-1/Gq/GTP/PLC beta complex (EDNRB-EDN1-GNA11_GNAQ_GNA15_GNA14-PLCB3_PLCB2_PLCB1)
(modification, collaborate)
Aramori et al., J Biol Chem 1992, Takuwa et al., Am J Physiol 1989, Resink et al., Biochem Biophys Res Commun 1988
Evidence: assay, other species
-
NCI Pathway Database Endothelins:
ETB receptor/Endothelin-1/Gq/GTP/PLC beta complex (EDNRB-EDN1-GNA11_GNAQ_GNA15_GNA14-PLCB3_PLCB2_PLCB1)
(modification, activates)
Aramori et al., J Biol Chem 1992, Takuwa et al., Am J Physiol 1989, Resink et al., Biochem Biophys Res Commun 1988
Evidence: assay, other species
-
NCI Pathway Database Endothelins:
ETB receptor/Endothelin-1/Gq/GTP/PLC beta complex (EDNRB-EDN1-GNA11_GNAQ_GNA15_GNA14-PLCB3_PLCB2_PLCB1)
→
None
(modification, activates)
Aramori et al., J Biol Chem 1992, Takuwa et al., Am J Physiol 1989, Resink et al., Biochem Biophys Res Commun 1988
Evidence: assay, other species
-
NCI Pathway Database Endothelins:
ETB (EDNRB)
→
ET1 (EDN1)
(modification, collaborate)
Klammt et al., FEBS J 2007*, Watanabe et al., Biochem Biophys Res Commun 1989
Evidence: physical interaction, other species
-
NCI Pathway Database Endothelins:
ETB (EDNRB)
→
ETB receptor/Endothelin-1 complex (EDNRB-EDN1)
(modification, collaborate)
Klammt et al., FEBS J 2007*, Watanabe et al., Biochem Biophys Res Commun 1989
Evidence: physical interaction, other species
-
NCI Pathway Database Endothelins:
ET1 (EDN1)
→
ETB receptor/Endothelin-1 complex (EDNRB-EDN1)
(modification, collaborate)
Klammt et al., FEBS J 2007*, Watanabe et al., Biochem Biophys Res Commun 1989
Evidence: physical interaction, other species
-
NCI Pathway Database Endothelins:
ETB receptor/Endothelin-1/Gq/GTP/PLC beta complex (EDNRB-EDN1-GNA11_GNAQ_GNA15_GNA14-PLCB3_PLCB2_PLCB1)
→
p38 alpha (MAPK14)
(modification, activates)
Aquilla et al., J Biol Chem 1996
Evidence: mutant phenotype, other species
-
NCI Pathway Database Endothelins:
Gq family/GDP complex (GNA11_GNAQ_GNA15_GNA14)
→
ETB receptor/Endothelin-1 complex (EDNRB-EDN1)
(modification, collaborate)
Aramori et al., J Biol Chem 1992
-
NCI Pathway Database Endothelins:
Gq family/GDP complex (GNA11_GNAQ_GNA15_GNA14)
→
ETB receptor/Endothelin-1/Gq/GTP complex (EDNRB-EDN1-GNA11_GNAQ_GNA15_GNA14)
(modification, collaborate)
Aramori et al., J Biol Chem 1992
-
NCI Pathway Database Endothelins:
None
→
ETB receptor/Endothelin-1 complex (EDNRB-EDN1)
(modification, collaborate)
Aramori et al., J Biol Chem 1992
-
NCI Pathway Database Endothelins:
None
→
ETB receptor/Endothelin-1/Gq/GTP complex (EDNRB-EDN1-GNA11_GNAQ_GNA15_GNA14)
(modification, collaborate)
Aramori et al., J Biol Chem 1992
-
NCI Pathway Database Endothelins:
ETB receptor/Endothelin-1 complex (EDNRB-EDN1)
→
ETB receptor/Endothelin-1/Gq/GTP complex (EDNRB-EDN1-GNA11_GNAQ_GNA15_GNA14)
(modification, collaborate)
Aramori et al., J Biol Chem 1992
-
NCI Pathway Database Endothelins:
ETB receptor/Endothelin-1 complex (EDNRB-EDN1)
→
None
(modification, collaborate)
Aramori et al., J Biol Chem 1992
-
NCI Pathway Database Endothelins:
ETB receptor/Endothelin-1/Gq/GTP complex (EDNRB-EDN1-GNA11_GNAQ_GNA15_GNA14)
→
None
(modification, collaborate)
Aramori et al., J Biol Chem 1992
-
NCI Pathway Database Endothelins:
ETB receptor/Endothelin-1/Gq/GTP/PLC beta complex (EDNRB-EDN1-GNA11_GNAQ_GNA15_GNA14-PLCB3_PLCB2_PLCB1)
→
PLC beta (PLCB3/PLCB2/PLCB1)
(modification, collaborate)
Aramori et al., J Biol Chem 1992
-
NCI Pathway Database Endothelins:
ETB receptor/Endothelin-1/Gq/GTP/PLC beta complex (EDNRB-EDN1-GNA11_GNAQ_GNA15_GNA14-PLCB3_PLCB2_PLCB1)
→
ETB receptor/Endothelin-1/Gq/GTP complex (EDNRB-EDN1-GNA11_GNAQ_GNA15_GNA14)
(modification, collaborate)
Aramori et al., J Biol Chem 1992
-
NCI Pathway Database Endothelins:
PLC beta (PLCB3/PLCB2/PLCB1)
→
ETB receptor/Endothelin-1/Gq/GTP complex (EDNRB-EDN1-GNA11_GNAQ_GNA15_GNA14)
(modification, collaborate)
Aramori et al., J Biol Chem 1992
-
Reactome Reaction:
EDN1
→
EDNRB
(direct_complex)
Nakamuta et al., Biochem Biophys Res Commun 1991*, Adachi et al., Biochem Biophys Res Commun 1991*, Inoue et al., Proc Natl Acad Sci U S A 1989*, Elshourbagy et al., J Biol Chem 1993*
-
Reactome Reaction:
EDN1
→
EDNRB
(reaction)
Rubio et al., Genomics 1999, Dowal et al., J Biol Chem 2006, Nakamuta et al., Biochem Biophys Res Commun 1991*, Adachi et al., Biochem Biophys Res Commun 1991*, Lambert et al., Science signaling 2008, Amatruda et al., Proc Natl Acad Sci U S A 1991, Inoue et al., Proc Natl Acad Sci U S A 1989*, Ferguson et al., J Biol Chem 1986, Elshourbagy et al., J Biol Chem 1993*, Chen et al., Biochim Biophys Acta 1996
-
WikiPathways Endothelin Pathways:
EDN1
→
EDNRB
(mim-stimulation)
-
WikiPathways Endothelin Pathways:
EDN1
→
EDNRB
(mim-stimulation)
-
WikiPathways Prostaglandin Synthesis and Regulation:
EDN1
→
EDNRB/EDNRA
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Zuccarello et al., J Cardiovasc Pharmacol 1999
:
The purpose of this study was to investigate whether
endothelin (ET)-1 activation of
ETB1 receptors influences the relative magnitude of ETA/ETB2 receptor mediated ET-1 constriction in the rabbit basilar artery
Doerr et al., Biol Reprod 2008
:
In summary, studies in ovine corpora lutea provided strong evidence that : 1 ) EDNRA, but not
EDNRB , mediates antisteroidogenic actions of EDN1, 2 ) actions of PGF2alpha are both independent of and dependent upon mediation by EDN1, and 3 ) small steroidogenic cells are
targets for antisteroidogenic effects of
EDN1
Pollock et al., Curr Opin Nephrol Hypertens 2008
:
Next, this review will outline the progression of data providing support for our hypothesis that an intra-renal mechanism of
endothelin activation of
ETB receptors stimulates NOS1 activity and nitric oxide production to promote sodium excretion
Thai et al., American journal of physiology. Renal physiology 2008
:
ADP-ribosyl cyclase and ryanodine receptors
mediate endothelin ETA and
ETB receptor induced renal vasoconstriction in vivo
Zhang et al., Am J Physiol Gastrointest Liver Physiol 2009
(Cholestasis...) :
Experimental hepatopulmonary syndrome (HPS) after common bile duct ligation ( CBDL ) in rat is accompanied by increased lung vascular endothelial
endothelin B (ETB) receptor expression and
increased circulating levels of
endothelin-1 (ET-1)
Wilson et al., Exp Cell Res 2012
:
Endothelin-1 activation of
ETB receptors leads to a reduced cellular proliferative rate and an increased cellular footprint
Mazzuca et al., Br J Pharmacol 2013
:
Endothelin-1 (ET-1) causes vasoconstriction via endothelin receptor type A ( ETA R ), but could
activate ETB R in the endothelium and release vasodilator substances
Ozaki et al., Biochem Biophys Res Commun 1995
:
ETB mediated regulation of extracellular levels of
endothelin-1 in cultured human endothelial cells
Pecci et al., J Steroid Biochem Mol Biol 1994
:
Infusion of Sarafotoxin 6b, an ETB agonist, also increased the aldosterone content of the adrenal and stimulated the ouabain-sensitive sodium potassium ATPase in the zona glomerulosa, further indicating that the effect of
endothelin is probably
mediated by
ETB or isopeptide non-specific endothelin receptor
Warner et al., Br J Pharmacol 1993
(Synaptic Transmission) :
Thus, both ETA receptors and
ETB receptors
mediate the effects of the
endothelin/sarafotoxinpeptides on neurotransmission
Noguchi et al., Br J Pharmacol 1996
(Bronchial Spasm) :
The inhibition by an ETA receptor antagonist and the restoration by a neutral endopeptidase (NEP) inhibitor of the second phase of bronchoconstriction suggests that primary activation of
ETB receptors
leads to autocrine/paracrine
endothelin-1 (ET-1) release that would subsequently cause profound bronchoconstriction through both ETA and ETB receptor activation
Lodge et al., Eur J Pharmacol 1995
:
Endothelin-1 induced force in the saphenous and jugular veins is normally
mediated by endothelin
ETB-like receptors
Holm et al., Eur J Pharmacol 1997
(Anoxia) :
The present results suggest that the pulmonary vasodilator effect of exogenously administered
endothelin-1 during acute hypoxia is
mediated by endothelin
ETB receptors in the pig
Zhang et al., J Hepatol 1997
:
Endothelin-1 induces liver vasoconstriction through both ETA and
ETB receptors
Hasselblatt et al., Brain Res 1998
:
ETA and
ETB receptor antagonists synergistically
increase extracellular
endothelin-1 levels in primary rat astrocyte cultures