Gene interactions and pathways from curated databases and text-mining

◀ Back to EDN1

EDN1 — EDNRB

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Zuccarello et al., J Cardiovasc Pharmacol 1999 : The purpose of this study was to investigate whether endothelin (ET)-1 activation of ETB1 receptors influences the relative magnitude of ETA/ETB2 receptor mediated ET-1 constriction in the rabbit basilar artery
Doerr et al., Biol Reprod 2008 : In summary, studies in ovine corpora lutea provided strong evidence that : 1 ) EDNRA, but not EDNRB , mediates antisteroidogenic actions of EDN1, 2 ) actions of PGF2alpha are both independent of and dependent upon mediation by EDN1, and 3 ) small steroidogenic cells are targets for antisteroidogenic effects of EDN1
Pollock et al., Curr Opin Nephrol Hypertens 2008 : Next, this review will outline the progression of data providing support for our hypothesis that an intra-renal mechanism of endothelin activation of ETB receptors stimulates NOS1 activity and nitric oxide production to promote sodium excretion
Thai et al., American journal of physiology. Renal physiology 2008 : ADP-ribosyl cyclase and ryanodine receptors mediate endothelin ETA and ETB receptor induced renal vasoconstriction in vivo
Zhang et al., Am J Physiol Gastrointest Liver Physiol 2009 (Cholestasis...) : Experimental hepatopulmonary syndrome (HPS) after common bile duct ligation ( CBDL ) in rat is accompanied by increased lung vascular endothelial endothelin B (ETB) receptor expression and increased circulating levels of endothelin-1 (ET-1)
Wilson et al., Exp Cell Res 2012 : Endothelin-1 activation of ETB receptors leads to a reduced cellular proliferative rate and an increased cellular footprint
Mazzuca et al., Br J Pharmacol 2013 : Endothelin-1 (ET-1) causes vasoconstriction via endothelin receptor type A ( ETA R ), but could activate ETB R in the endothelium and release vasodilator substances
Ozaki et al., Biochem Biophys Res Commun 1995 : ETB mediated regulation of extracellular levels of endothelin-1 in cultured human endothelial cells
Pecci et al., J Steroid Biochem Mol Biol 1994 : Infusion of Sarafotoxin 6b, an ETB agonist, also increased the aldosterone content of the adrenal and stimulated the ouabain-sensitive sodium potassium ATPase in the zona glomerulosa, further indicating that the effect of endothelin is probably mediated by ETB or isopeptide non-specific endothelin receptor
Warner et al., Br J Pharmacol 1993 (Synaptic Transmission) : Thus, both ETA receptors and ETB receptors mediate the effects of the endothelin/sarafotoxinpeptides on neurotransmission
Noguchi et al., Br J Pharmacol 1996 (Bronchial Spasm) : The inhibition by an ETA receptor antagonist and the restoration by a neutral endopeptidase (NEP) inhibitor of the second phase of bronchoconstriction suggests that primary activation of ETB receptors leads to autocrine/paracrine endothelin-1 (ET-1) release that would subsequently cause profound bronchoconstriction through both ETA and ETB receptor activation
Lodge et al., Eur J Pharmacol 1995 : Endothelin-1 induced force in the saphenous and jugular veins is normally mediated by endothelin ETB-like receptors
Holm et al., Eur J Pharmacol 1997 (Anoxia) : The present results suggest that the pulmonary vasodilator effect of exogenously administered endothelin-1 during acute hypoxia is mediated by endothelin ETB receptors in the pig
Zhang et al., J Hepatol 1997 : Endothelin-1 induces liver vasoconstriction through both ETA and ETB receptors
Hasselblatt et al., Brain Res 1998 : ETA and ETB receptor antagonists synergistically increase extracellular endothelin-1 levels in primary rat astrocyte cultures