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CD4 — PI3

Text-mined interactions from Literome

Trucy et al., Cell Immunol 2006 : We previously showed that CD4 binding induced a down-regulation of LFA-1-dependent-antigen independent adhesion of T and B lymphocytes in a phosphatidylinositol-3-kinase (PI3K) dependent manner
Mazerolles et al., J Immunol 1996 : These results strongly suggest that CD4 induced PI3-kinase activation, in the absence of concomitant TCR/CD3 triggering, leads to down-regulation of LFA-1 mediated T cell adhesion to B cells
Mazerolles et al., Eur J Immunol 1997 : Here we investigate the role of PI3-kinase in the inhibition of adhesion induced by gp160 binding to CD4