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CD4 — MPO

Text-mined interactions from Literome

Ooi et al., Proc Natl Acad Sci U S A 2012 (Glomerulonephritis...) : Transfer of an MPO ( 409-428 ) -specific CD4 ( + ) T-cell clone to Rag1 ( -/- ) mice induced focal necrotizing glomerulonephritis when glomerular MPO deposition was induced either by passive transfer of MPO-ANCA and LPS or by planting MPO ( 409-428 ) conjugated to a murine antiglomerular basement membrane mAb
Gan et al., J Am Soc Nephrol 2012 (Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis...) : Mast cell-deficient mice exhibited more antimyeloperoxidase CD4+ T cells, enhanced dermal delayed-type hypersensitivity responses to myeloperoxidase , and more severe focal necrotizing GN
Gan et al., Cell Immunol 2013 (Glomerulonephritis) : Therefore, MPO-ANCA can induce glomerulonephritis through both direct humoral mechanisms ( recruitment of neutrophils and deposition of MPO ) and indirectly by initiating MPO deposition in glomeruli, thereby directing effector CD4 ( + ) T cell mediated injury