Gene interactions and pathways from curated databases and text-mining

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CD4 — CD70

Text-mined interactions from Literome

Hashimoto-Okada et al., Int Immunol 2009 : The CD70-CD27 interaction during the stimulation with dendritic cells promotes naive CD4 ( + ) T cells to develop into T cells producing a broad array of immunostimulatory cytokines in humans ... However, it has not been extensively examined whether human primary DCs express CD70 and whether the CD70-CD27 interaction promotes naive CD4 ( + ) T cells to acquire the ability to produce effector cytokines during the DC-T cell interaction in humans
Arimoto-Miyamoto et al., Immunology 2010 : Stimulation with MoDCs promoted naive CD4 ( + ) T cells to acquire the ability to produce T helper type 1 and 2 cytokines in a CD70 dependent manner ... CD70 promotes naive CD4 ( + ) T cells to acquire immunostimulatory activity through the DC-T-cell and T-cell-T-cell interactions during the stimulation with MoDCs