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BDNF — PIK3CA
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Hetman et al., J Biol Chem 2002
:
Here, we report that inhibition of ERK1/2 increased the basal activity of GSK3beta in cortical neurons and that both ERK1/2 and
PI3K were
required for
brain derived neurotrophic factor (BDNF) suppression of GSK3beta activity ... Activation of both endogenous ERK1/2 and
PI3K signaling pathways was
required for
BDNF to block apoptosis induced by expression of recombinant GSK3beta
Mizuno et al., Mol Psychiatry 2003
:
Our findings suggested that
activation of
TrkB/PI3-K and protein synthesis signaling pathway by
BDNF in the hippocampus is important for spatial memory
Ruiz-León et al., J Neurochem 2004
(Neuroblastoma) :
Taken together, our results suggest that simultaneous activation of at least two signalling pathways, Ras/MAPK and
PI3K/Akt , is
necessary to mediate a full activation of the APP promoter by
BDNF
Almeida et al., Cell Death Differ 2005
(MAP Kinase Signaling System) :
The results indicate that the protective effect of
BDNF in hippocampal neurons against glutamate toxicity is
mediated by the
PI3-K and the Ras/MAPK signaling pathways, and involves a long-term change in protein synthesis
Laurino et al., J Cell Sci 2005
:
Our results show that IGF-1, but not
BDNF , significantly and rapidly
stimulates IRS/PI3K/Akt and membrane expansion
Li et al., Cell Death Differ 2007
(Neuroblastoma) :
Previously, we found
BDNF activation of TrkB through
PI3K/Akt protects NB from etoposide/cisplatin induced cell death
Yoshii et al., Nat Neurosci 2007
:
BDNF induces transport of PSD-95 to dendrites through
PI3K-AKT signaling after NMDA receptor activation
Chao et al., Brain Pathol 2011
:
More importantly,
BDNF activation of CK2 is not
affected by co-administration of the ERK1/2 inhibitor, PD98059, and the
PI3-K inhibitor, LY294002
Li et al., Behav Brain Res 2012
:
In cultured PC-12 cells,
BDNF activated
PI3K/Akt signaling through the TrkB receptor, whereas stimulation of ILK/Akt occurred through TrkA/p75 ( NTR ) heteroreceptor
Gouarné et al., Br J Pharmacol 2013
:
While
BDNF activates both the
PI3K/Akt and the ERK pathway, olesoxime induced only a late activation of the ERK pathways, which did not seem to play a major role in its neuroprotection against CPT. Rather, our results favour preserved mitochondrial membrane integrity by olesoxime
Yamada et al., J Biol Chem 1997
:
We examined how
BDNF activates
PI3-K in cultured cerebral cortical neurons ... IRS-1 and -2 were tyrosine phosphorylated and bound to
PI3-K in
response to
BDNF ... On the other hand, we observed no association of
PI3-K with TrkB in
response to
BDNF ... These results indicate that the activation of TrkB by
BDNF induces the activation of
PI3-K via IRS-1 and -2 rather than by a direct interaction of TrkB with PI3-K in cultured cortical neurons