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ANGPT2 — JAK2

Text-mined interactions from Literome

Shaw et al., J Neurosci 2003 (Pheochromocytoma) : We found that Ang II induced the activation of SHP-1 and that an antisense against SHP-1 not only augmented the nicotine induced tyrosine phosphorylation of JAK2 but also blocked the Ang II neutralization of the nicotine induced neuroprotection ... These results demonstrate that nicotine induced tyrosine phosphorylation of JAK2 and neuroprotection against Abeta ( 1-42 ) in PC12 cells are blocked by Ang II via AT2 receptor induced activation of SHP-1
Modesti et al., Diabetes 2005 (Heart Failure) : In nonfailing myocytes, JAK2 phosphorylation was enhanced by Ang II only in the presence of high glucose ( 25 mmol/l ) via Ang II type I (AT1) receptors ( +79 % vs. normal glucose, P < 0.05 ) ... In conclusion, in human nonfailing myocytes, high glucose allows Ang II to activate JAK2 signaling, whereas in failing myocytes, hyperglycemia alone is able to induce Ang II generation, which in turn activates JAK2 via enhanced oxidative stress
Banes-Berceli et al., American journal of physiology. Renal physiology 2006 (Diabetes Mellitus, Experimental...) : We also found that the activation of JAK2 by HG and ANG II was dependent on the Rho family of GTPases
Ohtsu et al., Arterioscler Thromb Vasc Biol 2006 (Hypertrophy) : However, Ang II comparably stimulated intracellular Ca2+ elevation and JAK2 tyrosine phosphorylation in these VSMCs
Kandalam et al., Regul Pept 2010 : In this study, we investigated whether Ang II induces Janus kinase (JAK) 2 , signal transducer and activators of transcription ( STAT ) 3 phosphorylation, and interleukin-6 (IL-6) secretion in cultured brainstem rat astrocytes ... The JAK2 inhibitor, AG490 ( 50 microM ), prevented Ang II JAK2 phosphorylation ... Our study showed for the first time that Ang II induced JAK2/STAT3 phosphorylation and IL-6 secretion through activation of the Ang II AT(1) receptor in brainstem astrocytes
Ketsawatsomkron et al., Vascul Pharmacol 2010 (Insulin Resistance) : Finally, we also showed that Ang II-induced activation of PTP-1B in VSMC was PKA/JAK2 dependent
Banes-Berceli et al., Am J Physiol Regul Integr Comp Physiol 2011 (Disease Models, Animal...) : Janus kinase (JAK) 2 is activated by ANG II in vitro and in vivo, and chronic blockade of JAK2 by the JAK2 inhibitor AG-490 has been shown recently to attenuate ANG II hypertension in mice
Marrero et al., Am J Physiol 1998 : ANG II stimulation activates the Janus kinase/signal transducers and activators of transcription ( JAK/STAT ) pathway by inducing tyrosine phosphorylation, activation, and association of JAK2 with the receptor