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SP1 — TMED7

Text-mined interactions from Literome

Andrés et al., Arterioscler Thromb Vasc Biol 2001 : In the present study, we demonstrate the interaction of the transcription factor Sp1 with 2 GC-rich sequences within the p27 promoter in cultured VSMCs. Importantly, point mutations that disrupted Sp1 binding markedly reduced p27 promoter activity, demonstrating that Sp1 is required for efficient p27 gene transcription in cultured VSMCs ... Collectively, these results demonstrate that Sp1 is essential for maximum p27 promoter activity in VSMCs and suggest that posttranslational induction of Sp1 DNA binding activity contributes to the induction of p27 expression and VSMC growth arrest at late time points after balloon angioplasty
Abdelrahim et al., Cancer Res 2004 (Pancreatic Neoplasms) : Small inhibitory RNAs for Sp3, but not Sp1 or Sp4, inhibited phosphorylation of retinoblastoma protein, blocked G0/G1 -- > S-phase progression, and up-regulated p27 protein/promoter activity of Panc-1 cells ; similar results were observed in other pancreatic cancer cells, suggesting that Sp3 dependent growth of pancreatic cancer cells is caused by inhibition of p27 expression