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IRAK1 — TLR1
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Endogenous TLR signaling:
IRAK2 (IRAK2)
→
HMGB1/TLR2/TLR1/MYD88/TIRAP/IRAK/IRAK2/IRAK4 complex (TLR2-TLR1-HMGB1-IRAK1-IRAK2-IRAK4-MYD88-TIRAP)
(modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database Endogenous TLR signaling:
IRAK4 (IRAK4)
→
HMGB1/TLR2/TLR1/MYD88/TIRAP/IRAK/IRAK2/IRAK4 complex (TLR2-TLR1-HMGB1-IRAK1-IRAK2-IRAK4-MYD88-TIRAP)
(modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database Endogenous TLR signaling:
IRAK (IRAK1)
→
HMGB1/TLR2/TLR1/MYD88/TIRAP complex (TLR2-TLR1-HMGB1-MYD88-TIRAP)
(modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database Endogenous TLR signaling:
IRAK (IRAK1)
→
HMGB1/TLR2/TLR1/MYD88/TIRAP/IRAK/IRAK2/IRAK4 complex (TLR2-TLR1-HMGB1-IRAK1-IRAK2-IRAK4-MYD88-TIRAP)
(modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database Endogenous TLR signaling:
HMGB1/TLR2/TLR1/MYD88/TIRAP complex (TLR2-TLR1-HMGB1-MYD88-TIRAP)
→
HMGB1/TLR2/TLR1/MYD88/TIRAP/IRAK/IRAK2/IRAK4 complex (TLR2-TLR1-HMGB1-IRAK1-IRAK2-IRAK4-MYD88-TIRAP)
(modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
-
WikiPathways Simplified Depiction of MYD88 Distinct Input-Output Pathway:
TLR1/TLR2/TLR4/TLR5/TLR6/TLR7/TLR8/TLR9/TLR10/IL1A
→
Complex of UBE2N-UBE2V1-TRAF6-TIFA-IRAK1
(activation)
Text-mined interactions from Literome
Kobayashi et al., Cell 2002
(Salmonella Infections) :
Thus,
IRAK-M regulates
TLR signaling and innate immune homeostasis
Hazeki et al., Eur J Immunol 2003
:
PP2, an inhibitor of Src family tyrosine kinases, prevented the TLR induced phosphorylation of paxillin and Pyk2 without affecting
TLR induced
IRAK activation
Zhang et al., Infect Immun 2005
(Pseudomonas Infections) :
We also determined that MyD88,
IRAK , TRAF6, and Toll interacting protein (Tollip), but not TIRAP, were involved in the
TLR mediated response to P. aeruginosa in HAECs
Kubo-Murai et al., J Biochem 2008
:
Stimulation of these cells with
TLR ligands did not
cause the degradation of
IRAK-1 , which was clearly observed in the parent cells
Kawagoe et al., Nat Immunol 2008
:
Thus, IRAK2 is critical in late-phase
TLR responses , and
IRAK1 and IRAK2 are essential for the initial responses to TLR stimulation
Nguyen et al., Cell Signal 2009
:
Phosphorylation of
IRAK-1 by IRAK-4 in
response to
TLR activation may then release IRAK-1 from the inhibitory constraint exerted by its C-terminal domain
Cho et al., J Cell Physiol 2010
(Calcinosis) :
Overexpression of miR-146a induced the inhibition of
IRAK1 expression and inhibited basal and TNF-alpha- and
TLR ligand
induced osteogenic differentiation
Kumar Pachathundikandi et al., PloS one 2011
(Helicobacter Infections) :
Using phospho-specific antibodies and luciferase reporter assays, we further demonstrate that H. pylori induces
IRAK-1 and I?B phosphorylation in a
TLR dependent manner, and this was required for activation of transcription factor NF-?B