Gene interactions and pathways from curated databases and text-mining

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CAV2 — SP1

Text-mined interactions from Literome

Bist et al., Biochemistry 2000 : Okadaic acid, previously shown to inhibit growth, FC efflux, and caveolin expression, inhibited E2F/Sp1 binding, while higher concentrations of extracellular FC increased it
Dasari et al., Cancer Res 2006 : In addition, signaling studies show p38 mitogen activated protein kinase ( MAPK ) as the upstream regulator of Sp1 mediated activation of the caveolin-1 promoter following oxidative stress ... Inhibition of p38 MAPK prevents the oxidant induced Sp1 mediated up-regulation of caveolin-1 protein expression and development of premature senescence