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PARP1 — TNF

Text-mined interactions from Literome

Sharp et al., Inflammation 2001 (Inflammation) : PARP inhibition with GPI 6150 blocked the IL-1beta mediated stimulation of both ICAM-1 and E-selectin expression, and blocked TNF-alpha stimulation of ICAM-1 expression at 24 h
Los et al., Mol Biol Cell 2002 (Necrosis) : Our results indicate that TNF induces PARP activation leading to ATP depletion and subsequent necrosis
Epperly et al., Exp Hematol 2003 : The cell lines overexpressing MnSOD ( 1F2 or 2C6 ) displayed decreased radiation induced, TNF-alpha induced, or IL-3 withdrawal induced mitochondrial membrane permeability, caspase-3 and PARP activation, and apoptosis
Carrillo et al., Nucleic Acids Res 2004 (Inflammation) : Transcription regulation of TNF-alpha-early response genes by poly(ADP-ribose) polymerase-1 in murine heart endothelial cells
Virág et al., Med Sci Monit 2004 (Asthma...) : The production of TNF- alpha and IL-12, but not IL-5 or IL-13, was also suppressed by PARP inhibition
Nakajima et al., J Biol Chem 2004 (Inflammation) : PARP-1 inhibitors and the antisense RNA for PARP-1 mRNA suppressed lipopolysaccharide (LPS) induced expression of tumor necrosis factor-alpha and inducible nitric-oxide synthase, suggesting that PARP-1 activity has a critical role in synthesis
Murata-Ohsawa et al., Int J Mol Med 2004 : As the molecular mechanism involved, we showed Delta-1 stimulation partially suppressed the sequential activation of caspase-8, caspase-3, and, PARP induced by TNF-alpha
Han et al., J Exp Med 2005 (Calcium Signaling...) : Both compounds blocked TNF induced activation of Rap1A , a phox associated guanosine triphosphatase that is regulated by cAMP
Ono et al., J Biol Chem 2009 (Neuroblastoma) : Moreover, we found that tumor necrosis factor-alpha enhanced MOR gene expression as well as increased PARP-1 binding to the G ( -172 ) -- > T region and G ( -172 ) -- > T-dependent transcription in SH-SY5Y cells
Jog et al., J Immunol 2009 (Autoimmune Diseases...) : PARP-1 also regulated TNF-alpha expression and up-regulation of adhesion molecules, further supporting a role of PARP-1 in the inflammatory process within the kidney
Huang et al., Biochem Biophys Res Commun 2009 (Disease Models, Animal...) : Minocycline repressed the expression of TNF-alpha , IL-1beta, and iNOS, decreased the apoptotic index, and inhibited poly(ADP-ribose) polymerase-1 ( PARP-1 ) activity in the mouse small intestine
Waiwut et al., Mol Cell Biochem 2011 : Gomisins A and N strongly promoted TNF-a induced cleavage of caspase-3 and PARP-1 , which are key markers of apoptosis
Czapski et al., Neurochem Int 2013 (Inflammation) : However, PARP activity had no effect on the mRNA level of COX-2, TNF-a and NADPH oxidase in the hippocampus
Ha Thi et al., Biochim Biophys Acta 2013 (MAP Kinase Signaling System...) : TNF-a and TGF-ß synergistically induced the degradation of poly ( ADP-ribose ) polymerase ( PARP ) and caspase cascade activation
Sleijfer et al., Int J Cancer 1998 (Carcinoma, Small Cell...) : Moreover, it was demonstrated that combining TNF with the poly-ADP-ribose polymerase ( PARP ) inhibitors 6-aminonicotinamide and 3-aminobenzamide did not affect TNF-sensitivity in GLC4 and GLC4-Adr350x, excluding a pivotal role of PARP in TNF-resistance in these cell lines