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NCF2 — NOX5
Text-mined interactions from Literome
Rinckel et al., Biochem Biophys Res Commun 1999
:
Rac is a GTPase that in the GTP bound state binds
p67phox to
activate NADPH oxidase
Xiao et al., Am J Physiol Cell Physiol 2002
(Cardiomegaly...) :
We found that ARVM express gp91(phox), p22(phox),
p67(phox) , and p47(phox), four major components of NAD ( P ) H oxidase, and that alpha ( 1 ) -AR stimulated ERK1/2 activation was
blocked by four structurally unrelated inhibitors of
NAD ( P ) H oxidase [ diphenyleneiodonium, phenylarsine oxide, 4- ( 2-aminoethyl ) benzenesulfonyl fluoride, and cadmium ]
Teissier et al., Circ Res 2004
(Inflammation) :
The PPAR-alpha induced increase in ROS was attributable to the induction of
NADPH oxidase , because ( 1 ) preincubation with the NADPH oxidase inhibitor diphenyleneiodinium prevented the increase in ROS production ; ( 2 ) PPAR-alpha agonists increased production measured by superoxide dismutase-inhibitable cytochrome c reduction ; ( 3 ) PPAR-alpha agonists
induced mRNA levels of the NADPH oxidase subunits p47(phox),
p67phox , and gp91phox and membrane p47phox protein levels ; and ( 4 ) induction of ROS production was abolished in p47phox-/- and gp91phox-/- macrophages
Miyata et al., J Am Soc Nephrol 2005
:
Pre-incubation with the selective mineralocorticoid receptor ( MR ) antagonist, eplerenone ( 10 micromol/L ), significantly attenuated aldosterone induced O ( 2 ) ( - ) production,
NADPH oxidase activation and membranous translocation of p47phox and
p67phox
Kim et al., J Leukoc Biol 2006
:
Impaired
NADPH oxidase activity in Rac2-deficient murine neutrophils does not
result from defective translocation of p47phox and
p67phox and can be rescued by exogenous arachidonic acid
Ming et al., Mol Cell Biol 2007
:
The Rac effector
p67phox regulates phagocyte
NADPH oxidase by stimulating Vav1 guanine nucleotide exchange activity
Wang et al., Free Radic Biol Med 2007
(Brain Ischemia...) :
Ethanol ingestion was associated with translocation of the NADPH oxidase subunit
p67(phox) from hippocampal cytosol fraction to membrane,
increased NADPH oxidase activity in hippocampus within the first hour after gavage, and increased lipid peroxidation ( 4-hydroxy-2-nonenal ) in plasma and hippocampus within the first 2 h after gavage
Choi et al., J Biol Chem 2008
:
Ang II enhanced the activity of both Nox1 and
Nox2 supported by either adaptor pair, with more effective activation of Nox1 in the presence of NOXO1 and NOXA1 and of Nox2 in the
presence of p47(phox) and
p67(phox)
Tian et al., Am J Physiol Regul Integr Comp Physiol 2008
(Disease Models, Animal...) :
By day 35 in the high-Na S rats, mRNA expression of renal cortical gp91phox, p22phox, p47phox, and
p67phox NADPH subunits in S rats increased markedly, and treatment of high-Na S rats with the NADPH oxidase inhibitor apocynin
resulted in significant decreases in mRNA expression of these
NADPH oxidase subunits
Raad et al., FASEB J 2009
(Granulomatous Disease, Chronic) :
Regulation of the phagocyte
NADPH oxidase activity : phosphorylation of gp91phox/NOX2 by protein kinase C
enhances its diaphorase activity and binding to Rac2,
p67phox , and p47phox
Zhang et al., Nephrology (Carlton) 2009
:
The cells were treated with 10 ng/mL TGF-beta1, either in the presence or absence of the
NAD ( P ) H oxidase inhibitor, diphenyleneiodonium ( DPI ), or short hairpin RNA ( shRNA )
suppressing p67phox expression
Nisimoto et al., Biochemistry 2010
:
NADPH oxidase 4 (Nox4) is constitutively active, while
Nox2 requires the cytosolic regulatory subunits p47(phox) and
p67(phox) and activated Rac with activation by phorbol 12-myristate 13-acetate ( PMA )
Miyamoto et al., Biochim Biophys Acta 1994
:
Our data demonstrate that the appearance of
NADPH oxidase activity during eosinophilic differentiation is
dependent on the levels of p47-phox and
p67-phox cytosolic proteins translocated to the plasma membrane and the amount of cytochrome b-558 in the membrane as observed with neutrophils and monocytes
Dusi et al., Biochem J 1993
(Granulomatous Disease, Chronic) :
Activation of
NADPH oxidase of human neutrophils
involves the phosphorylation and the translocation of cytosolic
p67phox
Dorseuil et al., J Biol Chem 1996
:
These results indicate that activated Rac can
regulate NADPH oxidase by interacting with
p67phox and that Rac2 is the main p67phox interacting GTPase in human cells
Leusen et al., J Exp Med 1996
(Granulomatous Disease, Chronic) :
In contrast to normal neutrophils, in which p47-phox and p67-phox translocate to the plasma membrane upon cell activation, the cells of the patient did not show this translocation, indicating that an interaction between
p67-phox and p21-rac1 is
essential for translocation of these cytosolic proteins and activation of the
NADPH oxidase
Swain et al., J Biol Chem 1997
:
Activation of the neutrophil
NADPH oxidase requires translocation of cytosolic proteins p47(phox),
p67(phox) , and Rac to the plasma membrane or phagosomal membrane, where they assemble with membrane bound flavocytochrome b