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NOTCH4 — SMAD4

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: SMAD4 — NOTCH4 (physical association, affinity chromatography technology) Sun et al., Oncogene 2005*
• IRef Hprd Interaction: SMAD4 — NOTCH4 (in vitro) Sun et al., Oncogene 2005*
• IRef Hprd Interaction: SMAD4 — NOTCH4 (in vivo) Sun et al., Oncogene 2005*

Text-mined interactions from Literome

Abe et al., Mech Dev 2005 : Notch signal activation restored the ability of C-terminal phosphorylated smad2 to bind to smad4 , resulting in a delay in the onset of LMC
Fu et al., J Biol Chem 2009 : This is the first evidence that Notch activation affects R-Smad expression and that cooperative induction of histone acetylation at specific promoters underlies the selective synergy between Notch and TGFbeta signaling pathways
Grabias et al., American journal of physiology. Renal physiology 2013 (Fibrosis...) : Depletion of Notch4 in shear stimulated PTECs eventually increases the levels of active TGF-ß1 protein by approximately fivefold, recovers stable SMAD phosphorylation and ubiquitinated SMAD species, and attenuates collagen accumulation