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MAPK3 — PAK3
Text-mined interactions from Literome
Zang et al., J Biol Chem 2002
:
The extent of binding to Raf-1 is correlated with the ability of
Pak to phosphorylate Raf and
induce mitogen activated protein kinase activation
De la Mota-Peynado et al., J Biol Chem 2011
(MAP Kinase Signaling System) :
Collectively, our results identify the Erk3 protein as a novel class I Pak substrate and further suggest a
role for
Pak kinase activity in atypical
MAPK signaling
Malarkannan et al., J Immunol 2012
:
This includes actin polymerization, tubulin multimerization, microtubule organizing center formation, calcium/calmodulin signaling,
Pak/Raf/Mek1/2 mediated
Erk1/2 activation, formation of maestrosome, E-cadherin, and CD44 mediated signaling and glycogen synthase kinase-3/adenomatous polyposis coli mediated ß-catenin activation
Huang et al., Mol Cell Biol 1998
:
These data indicate that separate signals are required for activation and inactivation of Paks and that, in contrast to other cell types, activated
Pak does not
trigger activation of JNK or
p38-MAPK in neutrophils