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JUN — REN

Text-mined interactions from Literome

Tamura et al., Biochim Biophys Acta 1993 : Activation of mouse renin promoter by cAMP and c-Jun in a kidney derived cell line
Tamura et al., Kidney Int 1998 : Possible role of c-Jun in transcription of the mouse renin gene ... In this study, we examined a possible role of c-Jun in the transcription of renin gene ... Furthermore, we examined the effects of c-Jun on transcription of the renin gene in enriched juxtaglomerular ( JG ) cells by cotransfection with pSV-c-Jun and by treatment with antisense c-jun oligodeoxynucleotides ... The overexpression of c-Jun activated the renin promoter in renin expressing JG cells, and antisense c-jun decreased the activity of renin promoter and expression of renin mRNA in JG cells ... These results indicate that the RC element plays a role in c-Jun mediated transcriptional regulation of the renin gene in HEK cells, and suggest that c-Jun participates in the regulation of renin gene expression in JG cells of the kidney