Gene interactions and pathways from curated databases and text-mining

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HSPG2 — JUN

Text-mined interactions from Literome

Qu et al., Blood 2004 : The antigen induced tyrosine phosphorylation of FcepsilonRI, Syk, phospholipase C-gamma (PLC-gamma) , activation of c-Jun N-terminal kinase (JNK) , extracellular signal regulated kinase ( ERK ), inhibitor of nuclear factor kappaB kinase ( IKK ), and Ca++ influx were all suppressed in the cells overexpressing Cbl-b in the lipid raft
Singal et al., Mol Cell Biochem 2009 : Increases in c-Fos and c-Jun gene expression due to NE were attenuated by both prazosin and a PLC inhibitor, U73122 ... It is suggested that c-Fos and c-Jun gene expression is regulated by PLC in adult cardiomyocytes through a PKC- and ERK1/2 dependent pathway