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ARNT — JUN
Pathways - manually collected, often from reviews:
-
BioCarta hypoxia-inducible factor in the cardivascular system:
HIF-1-alpha/ARNT/CREB/p300/JAB1/c-JUN complex (HIF1A-ARNT-CREB1-EP300-COPS5-JUN)
→
Endothelin 1 (EDN1)
(transcription, activates)
-
BioCarta hypoxia-inducible factor in the cardivascular system:
ARNT
→
c-JUN (JUN)
(modification, collaborate)
-
BioCarta hypoxia-inducible factor in the cardivascular system:
ARNT
→
HIF-1-alpha/ARNT/CREB/p300/JAB1/c-JUN complex (HIF1A-ARNT-CREB1-EP300-COPS5-JUN)
(modification, collaborate)
-
BioCarta hypoxia-inducible factor in the cardivascular system:
p300 (EP300)
→
HIF-1-alpha/ARNT/CREB/p300/JAB1/c-JUN complex (HIF1A-ARNT-CREB1-EP300-COPS5-JUN)
(modification, collaborate)
-
BioCarta hypoxia-inducible factor in the cardivascular system:
CREB (CREB1)
→
HIF-1-alpha/ARNT/CREB/p300/JAB1/c-JUN complex (HIF1A-ARNT-CREB1-EP300-COPS5-JUN)
(modification, collaborate)
-
BioCarta hypoxia-inducible factor in the cardivascular system:
JAB1 (COPS5)
→
HIF-1-alpha/ARNT/CREB/p300/JAB1/c-JUN complex (HIF1A-ARNT-CREB1-EP300-COPS5-JUN)
(modification, collaborate)
-
BioCarta hypoxia-inducible factor in the cardivascular system:
HIF-1-alpha (HIF1A)
→
HIF-1-alpha/ARNT/CREB/p300/JAB1/c-JUN complex (HIF1A-ARNT-CREB1-EP300-COPS5-JUN)
(modification, collaborate)
-
BioCarta hypoxia-inducible factor in the cardivascular system:
aspartylpeptide beta-dioxygenase (ASPH)
→
HIF-1-alpha/ARNT/CREB/p300/JAB1/c-JUN complex (HIF1A-ARNT-CREB1-EP300-COPS5-JUN)
(modification, inhibits)
-
BioCarta hypoxia-inducible factor in the cardivascular system:
c-JUN (JUN)
→
HIF-1-alpha/ARNT/CREB/p300/JAB1/c-JUN complex (HIF1A-ARNT-CREB1-EP300-COPS5-JUN)
(modification, collaborate)
-
BioCarta hypoxia-inducible factor in the cardivascular system:
HIF-1-alpha/ARNT/CREB/p300/JAB1/c-JUN complex (HIF1A-ARNT-CREB1-EP300-COPS5-JUN)
→
VEGF
(transcription, activates)
-
BioCarta hypoxia-inducible factor in the cardivascular system:
HIF-1-alpha/ARNT/CREB/p300/JAB1/c-JUN complex (HIF1A-ARNT-CREB1-EP300-COPS5-JUN)
→
l-lactate dehydrogenase (LDHA)
(transcription, activates)
-
NCI Pathway Database HIF-1-alpha transcription factor network:
AP1 complex (FOS-JUN)
→
HIF1A/ARNT complex (HIF1A-ARNT)
(transcription, activates)
Yamashita et al., J Biol Chem 2001
Evidence: mutant phenotype, reporter gene, physical interaction
Text-mined interactions from Literome
Huang et al., Cell Mol Life Sci 2010
:
EGF induced promoter activity and the mRNA level of 12(S)-lipoxygenase as well as the association between
c-Jun and Sp1 were
reduced by
ARNT knockdown
Liang et al., Int J Cancer 2012
(Carcinoma, Hepatocellular...) :
Screening by quantitative reverse-transcription PCR and PCR arrays revealed that cyclin E1, CDK2, Fos and
Jun were negatively
regulated by
ARNT , whereas CDKN1C, CNKN2A, CDKN2B, MAPK11 and MAPK14 were positively regulated in HCC