◀ Back to IRF6
IRF6 — STAT5A
Text-mined interactions from Literome
Stoiber et al., J Immunol 1999
:
Further consistent with inhibitory activity of SOCS3,
LPS also
inhibited the JAK2 dependent activation of
Stat5 by GM-CSF
Kimura et al., Proc Natl Acad Sci U S A 2005
:
We found that
LPS directly
activated Jak2 and
Stat5 , whereas SOCS-1 inhibited LPS induced Jak2 and Stat5 activation
Huang et al., J Clin Invest 2007
(Inflammation...) :
Enforced expression of STAT1,
IRF-1 , or GATA-1
enhanced phosphorylation of STAT1, STAT3, and
STAT5 in cultured Gata1-deficient murine megakaryocytes, with concomitant megakaryocyte maturation
Nam et al., J Pept Sci 2012
:
Western blotting revealed that
LPS induced
activation of STAT1 and
STAT5 in macrophages was significantly inhibited by CopA3
Yamaoka et al., J Immunol 1998
:
Consequently,
LPS induced activation of
STAT5 in human monocytes, and this STAT5 activation occurred in an indirect way via granulocyte-macrophage CSF (GM-CSF) secreted by LPS stimulated monocytes ... Taken together, these results suggest that in addition to other transcription factors,
STAT5 plays an important role in activation of monocytes by
LPS , and that STAT5 is another target for IL-10 and Dex to inhibit COX-2 expression in activated monocytes