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Li et al., Cardiovasc Res 2009
(Disease Models, Animal...) :
In cultured adult rat cardiomyocytes,
LPS ( 1 microg/mL )
induced calpain and caspase-3 activity, and up-regulated TNF-alpha expression
Cui et al., Acta Pharmacol Sin 2013
(Atherosclerosis) :
In the presence of the Ca ( 2+ ) chelator BAPTA ( 0.5 mmol/L ),
LPS induced increase of
calpain activity was also abolished ...
LPS stimulates NHE1 activity, increases [ Ca ( 2+ ) ] ( i ), and
activates calpain , which leads to endothelial cell apoptosis related to decreased Bcl-2 expression