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CCL5 — IFNG
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Hillyer et al., Clin Exp Immunol 2003
:
In combination with TNF-alpha,
IFN-gamma suppressed CXCL8 but enhanced
CCL5 and CXCL10, whereas transforming growth factor ( TGF ) -beta reduced secretion of all chemokines
Traidl-Hoffmann et al., Int Arch Allergy Immunol 2006
:
Desloratadine and loratadine inhibited the constitutive and
IFN-gamma induced release of
CCL5 , CXCL8 and CXCL10 from keratinocytes, while the low release of CCL17 remained unchanged
Ko et al., Clin Exp Immunol 2007
(Asthma) :
Blood was collected from 24 steroid-naive asthmatics, 39 asthmatics on inhaled corticosteroid and 32 age- and sex matched controls for assay of T-bet expression, specific IgE and chemokines ( interferon-gamma inducible protein-10 ( IP-10/CXCL10 ), monokines
induced by
interferon-gamma ( MIG/CXCL9 ), monocyte chemotactic protein-1 ( MCP-1/CCL2 ), regulated upon activation normal T cell expressed and secreted (
RANTES/CCL5 ) and interleukin-8 ( IL-8/CXCL8 ) levels
Taubert et al., Vet Res Commun 2008
:
Furthermore,
IFNgamma-stimulation led to a strong upregulation in the transcription of VCAM-1, ICAM-1, CXCL10 and CCL2 genes and to a low to moderate increase in the E- and P-selectin, CXCL1, CXCL8,
CCL5 , COX-2 and iNOS gene transcripts, but failed to enhance GM-CSF gene transcription
Machado et al., Microbes Infect 2008
:
Interestingly, T. cruzi infected NOS2-deficient CMs produced significantly higher levels of CCL2, CCL4,
CCL5 and CXL2 in the
presence of
IFN-gamma and TNF
Xu et al., Stem Cells 2009
:
C/EBPbeta knockdown also inhibited the synergistic expression of CXCL1, inducible nitric oxide synthase, and
CCL5 in
response to concomitant
IFNgamma and TNFalpha
Homma et al., Int Arch Allergy Immunol 2010
:
Cooperative
activation of
CCL5 expression by TLR3 and tumor necrosis factor-alpha or
interferon-gamma through nuclear factor-kappaB or STAT-1 in airway epithelial cells