◀ Back to CDH1
CDH1 — SRC
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
Src (SRC)
→
E-cadherin/beta catenin/alpha catenin complex (CDH1-CTNNB1-CTNNA1)
(modification, activates)
Fujita et al., Nat Cell Biol 2002, Palacios et al., Mol Cell Biol 2005
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
Src (SRC)
→
E-cadherin/beta catenin complex (CDH1-CTNNB1)
(modification, activates)
Fujita et al., Nat Cell Biol 2002, Palacios et al., Mol Cell Biol 2005
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met):
E-cadherin/beta catenin/alpha cateninNUMB/Par3/Par6/Atypical PKCs complex (CDH1-NUMB-CTNNB1-CTNNA1-F2RL2-PARD6A-PRKCI_PRKCZ)
→
Src (SRC)
(modification, collaborate)
Wang et al., EMBO J 2009
Evidence: physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
Src (SRC)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(modification, activates)
Roura et al., J Biol Chem 1999, Piedra et al., J Biol Chem 2001, Fujita et al., Nat Cell Biol 2002, Duchesne et al., J Biol Chem 2003, Simoneau et al., Cell Signal 2011
Evidence: assay, physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin complex (CDH1-JUP-CTNNA1-CTNND1)
→
Src (SRC)
(modification, collaborate)
Miravet et al., Mol Cell Biol 2003, Shibamoto et al., Cell adhesion and communication 1994
Evidence: mutant phenotype, assay
-
NCI Pathway Database E-cadherin signaling in keratinocytes:
E-cadherin/beta catenin-gamma catenin complex (CDH1-CTNNB1_JUP)
→
Src (SRC)
(modification, collaborate)
Xie et al., Mol Biol Cell 2005, Calautti et al., J Cell Biol 1998
Evidence: assay, physical interaction, other species
-
NCI Pathway Database E-cadherin signaling in keratinocytes:
Src (SRC)
→
E-cadherin/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1_JUP-CTNNA1-CTNND1)
(modification, activates)
Xie et al., Mol Biol Cell 2005, Calautti et al., J Cell Biol 1998
Evidence: assay, physical interaction, other species
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
SRC
—
CDH1
(physical association, affinity chromatography technology)
Genda et al., Lab Invest 2000*
-
IRef Biogrid Interaction:
SRC
—
CDH1
(physical association, affinity chromatography technology)
Swaminathan et al., Oncogene 2012*
-
IRef Biogrid Interaction:
SRC
—
CDH1
(physical association, affinity chromatography technology)
Shen et al., J Biol Chem 2008
-
MIPS CORUM Polycystin-1 multiprotein complex (ACTN1, CDH1, SRC, JUP, VCL, CTNNB1, PXN, BCAR1, PKD1, PTK2, TLN1):
Polycystin-1 multiprotein complex (ACTN1, CDH1, SRC, JUP, VCL, CTNNB1, PXN, BCAR1, PKD1, PTK2, TLN1) complex (ACTN1-BCAR1-CDH1-CTNNB1-JUP-PKD1-PTK2-PXN-SRC-TLN1-VCL)
Geng et al., Biochim Biophys Acta 2000
-
IRef Corum Interaction:
Complex of 12 proteins
(association, cosedimentation through density gradient)
Geng et al., Biochim Biophys Acta 2000
-
IRef Intact Interaction:
Complex of CBLL1-CDH1-SRC
(association, anti bait coimmunoprecipitation)
Swaminathan et al., Oncogene 2012*
-
IRef Intact Interaction:
SRC
—
CDH1
(physical association, anti bait coimmunoprecipitation)
Swaminathan et al., Oncogene 2012*
Text-mined interactions from Literome
Menke et al., Cancer Res 2001
(Pancreatic Neoplasms) :
Our data demonstrate that specific collagens are able to promote metastatic behavior by down-regulation of
E-cadherin gene expression in a
Src-kinase dependent manner
Kawai et al., Gastroenterology 2002
(Neoplasm Invasiveness) :
Activation of
Src by TNF-alpha
led to reduced
E-cadherin levels and enhanced invasion of src transfectants
Weis et al., J Clin Invest 2004
(Edema...) :
Src blockade
stabilizes a
Flk/cadherin complex, reducing edema and tissue injury following myocardial infarction
Wallez et al., Oncogene 2007
:
Finally, we found that in a VEGF induced wound healing assay,
cadherin adhesive activity was
impaired by
Src kinase inhibitors
McLachlan et al., Mol Biol Cell 2007
:
Finally, our data implicate PI3-kinase signaling as a target for
cadherin activated
c-Src signaling that contributes to its positive impact on cadherin function ... We conclude that
E-cadherin signaling is an important
activator of
c-Src at cell-cell contacts, providing a key input into a signaling pathway where quantitative changes in signal strength may result in qualitative differences in functional outcome
Shen et al., J Biol Chem 2008
:
Silencing Cdc42 blocks activation of EGFR and
Src induced by Ca2+ depletion, resulting in a reduction in
E-cadherin degradation
Bonazzi et al., Cell Microbiol 2008
:
Here we show that InlA triggers two successive E-cadherin post-translational modifications, i.e. the
Src mediated tyrosine phosphorylation of
E-cadherin followed by its ubiquitination by the ubiquitin-ligase Hakai
Tsygankova et al., Mol Cell Biol 2010
(Colorectal Neoplasms) :
Inhibition of
Src impaired spreading and
restored E-cadherin at cell/cell contacts
McLachlan et al., Cytoskeleton (Hoboken, N.J.) 2011
:
Protein tyrosine phosphatase activity is necessary for
E-cadherin activated
Src signaling ... Firstly, we report that upstream protein tyrosine phosphatase (PTP) activity is required to stimulate
E-cadherin activated
Src signaling at junctions ... Moreover,
E-cadherin homophilic ligation could not
stimulate Src signaling in vanadate treated cells ... Additionally, vanadate treatment phenocopied the effects of Src inhibition on the actin cytoskeleton, suggesting that PTP activity is required for the dynamic regulation of the actin cytoskeleton by
cadherin activated
Src signaling
Deep et al., Cancer prevention research (Philadelphia, Pa.) 2011
(Neoplasm Invasiveness...) :
Selective Src inhibition by dasatinib also showed increased E-cadherin expression in PC3 cells suggesting a possible
involvement of
Src inhibition in silibinin caused increase in
E-cadherin level
Alt-Holland et al., J Invest Dermatol 2011
(Carcinoma, Squamous Cell...) :
We found that
E-cadherin suppression triggered elevated mRNA and protein expression levels of focal adhesion kinase ( FAK ), and
increased FAK and
Src activities above the level seen in Ras expressing E-cadherin-competent keratinocytes ... The short hairpin RNA ( shRNA ) -mediated depletion of FAK and
Src restored
E-cadherin expression levels by increasing its stability in the membrane, and blocked tumor cell invasion in tissues ... These findings suggest that the tumor promoting effect of E-cadherin suppression, a common event in SCC development, is exacerbated by enhanced
E-cadherin degradation
induced by elevated FAK and
Src activities
Serrels et al., Cell Adh Migr 2011
(Neoplasms) :
Src/FAK mediated regulation of
E-cadherin as a mechanism for controlling collective cell movement : insights from in vivo imaging
Nagathihalli et al., Frontiers in bioscience (Landmark edition) 2012
(Carcinoma, Pancreatic Ductal...) :
Src mediated regulation of
E-cadherin and EMT in pancreatic cancer ... Recent studies have focused on
Src dependent regulation of
E-cadherin and other tumor progression related events such as EMT with the development of metastasis ... Although the molecular events associated with
Src dependent regulation of
E-cadherin are becoming better defined, the cellular processes that trigger the onset of EMT remain unclear
Yan et al., Stroke 2013
(Subarachnoid Hemorrhage) :
Downstream to PAR-1,
c-Src dependent activation of p21 activated kinase-1
led to an increased serine/threonine phosphorylation of vascular
endothelial-cadherin ; immunoprecipitation results revealed an enhanced binding of phosphorylated vascular endothelial-cadherin with endocytosis orchestrator ß-arrestin-2