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BCL6 — CCND2
Text-mined interactions from Literome
Kusam et al., Oncogene 2004
(Cell Transformation, Neoplastic) :
We found that in primary mouse B cells,
BCL-6 repressed expression of the Blimp-1, p27kip1, and
cyclin D2 target genes
Sun et al., Prostate 2008
(Disease Progression...) :
Bcl-xL overexpression significantly
increased the expression of
cyclin D2 , which might be responsible for Bcl-xL induced cell proliferation and tumor growth
Hirata et al., Br J Cancer 2009
(Neoplasm Invasiveness...) :
Our data indicate that
BCL6 interacts with nuclear translocated HB-EGF-CTF and that the nuclear export and degradation of BCL6
induces cyclin D2 upregulation ...
BCL6 degradation caused by the HB-EGF-CTF also might
induce cyclin D2 expression in human gastric cancers
Glauser et al., J Recept Signal Transduct Res 2009
:
Gain of function approaches indicated that FoxO activation was sufficient to activate bcl-6 transcription, while
Bcl-6 repressed
cyclin D2 transcription and proliferation