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AKT1 — UTP15
Text-mined interactions from Literome
Huwiler et al., Br J Pharmacol 2002
:
Furthermore, the ATP- and
UTP induced
PKB phosphorylation is abolished by two inhibitors of the PI 3-kinase ... In addition, suramin, a putative P2Y(2) receptor antagonist, and pertussis toxin, an inhibitor of G ( i ) /G ( o ) activation, markedly block ATP- and
UTP induced
PKB phosphorylation
Choi et al., Pancreas 2013
(Carcinoma, Pancreatic Ductal...) :
Activation of P2Y2 receptor by
UTP transduced to phospholipase C, inositol 1,4,5-triphosphate ( IP3 ), and protein kinase C. Uridine triphosphate induced proliferation was
mediated by protein kinase D, Src-family tyrosine kinase, Ca/calmodulin dependent protein kinase II, phosphatidylinositol 3-kinase (PI3K),
Akt , and phospholipase D. Uridine triphosphate increased phosphorylation of Akt through protein kinase C, Src-family tyrosine kinase, Ca/calmodulin dependent protein kinase II, and PI3K