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AKT1 — SPARC
Text-mined interactions from Literome
Shi et al., J Biol Chem 2004
(Glioma) :
Exogenous
SPARC rapidly
induces AKT phosphorylation, an effect that is blocked by a neutralizing SPARC antibody
Shi et al., Oncogene 2007
(Brain Neoplasms...) :
SPARC expression in glioma cells promotes invasion and survival under stress, the latter process dependent on
SPARC activation of
AKT ... Downregulation of either FAK or ILK expression inhibited
SPARC mediated
AKT phosphorylation, and targeting both FAK and ILK attenuated AKT activation more potently than targeting either FAK or ILK alone
Said et al., Am J Pathol 2007
(Neoplasm Invasiveness...) :
Moreover,
SPARC significantly
suppressed both anchorage dependent and -independent activation of
AKT and mitogen-acti vated protein kinase survival signaling pathways in ovarian cancer cells in response to serum and epidermal growth factor stimulation
Thomas et al., Neuro Oncol 2010
(Brain Neoplasms...) :
PTEN augments
SPARC suppression of proliferation and
inhibits SPARC induced migration by suppressing SHC-RAF-ERK and
AKT signaling
Fenouille et al., Oncogene 2011
(Melanoma) :
Conversely, increased expression of
SPARC stimulates
Akt and MDM2 phosphorylation, thus facilitating p53 degradation
Bhoopathi et al., PloS one 2012
(Neuroblastoma) :
SPARC overexpression inhibits cell proliferation in neuroblastoma and is partly
mediated by tumor suppressor protein PTEN and
AKT ... Additionally,
SPARC overexpression significantly
suppressed the activity of
AKT and this suppression was accompanied by an increase in the tumor suppressor protein PTEN both in vitro and in vivo