Koyama et al., Mol Cancer Ther 2007
(MAP Kinase Signaling System) :
p15(INK4b) induction was caused by MAPK/ERK kinase inhibitor ( PD98059 ), but not by Akt inhibitor ( SH-6, Akt-III )
Katayama et al., Oncogene 2008
:
Inhibition of Akt signaling by PI3K inhibitors, a PDK1 inhibitor, or dominant negative Akt transfection increased expression of p15(INK4b) and p19(INK4d) but not p16(INK4a) and p18(INK4c)