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ABL1 — EGR1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Fukada et al., J Biol Chem 2001
:
The binding of
Egr-1 to PRS is
suppressed by p210
Bcr-Abl due to the inhibition of Egr-1 expression, resulting in the enhancement of PTP1B promoter activity
Stuart et al., Oncogene 2005
(MAP Kinase Signaling System) :
Microarray analysis indicated that
Early Growth Response-1 (EGR1) gene expression is
induced by
c-Abl kinase activity, which was confirmed at the message and protein levels ... PD 95089, a specific inhibitor of MEK/ERK signaling, attenuated
c-Abl mediated upregulation of
EGR1 expression in a dose dependent manner ... Significantly, hydrogen peroxide induced
EGR1 expression appears to be
mediated by
c-Abl , as cells expressing dominant negative c-Abl, and c-Abl-/- murine embryonic fibroblasts, are completely defective in hydrogen peroxide induced EGR1 expression
Bhattacharyya et al., Oncogene 2009
(Fibrosis) :
Furthermore,
Abl kinase activity was
necessary for the induction of
Egr-1 by TGF-beta in normal fibroblasts, and Egr-1 was required for stimulation of collagen by Bcr-Abl