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IL2 — SYK
Pathways - manually collected, often from reviews:
-
BioCarta il 2 signaling pathway:
IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3/LCK/SYK complex (IL2-IL2RA-JAK3-JAK1-SYK-IL2RG-IL2RB-LCK)
→
SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1)
(modification, activates)
-
BioCarta il 2 signaling pathway:
SYK
→
IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2)
(modification, collaborate)
-
BioCarta il 2 signaling pathway:
SYK
→
IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3/LCK/SYK complex (IL2-IL2RA-JAK3-JAK1-SYK-IL2RG-IL2RB-LCK)
(modification, collaborate)
-
BioCarta il 2 signaling pathway:
IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2)
→
IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3/LCK/SYK complex (IL2-IL2RA-JAK3-JAK1-SYK-IL2RG-IL2RB-LCK)
(modification, collaborate)
-
BioCarta il 2 signaling pathway:
LCK
→
IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3/LCK/SYK complex (IL2-IL2RA-JAK3-JAK1-SYK-IL2RG-IL2RB-LCK)
(modification, collaborate)
-
NCI Pathway Database IL2-mediated signaling events:
SYK (SYK)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3)
(modification, collaborate)
Zhou et al., Mol Cell Biol 2000, Jiang et al., Blood 2003, Minami et al., Immunity 1995
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IL2-mediated signaling events:
SYK (SYK)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SYK complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SYK)
(modification, collaborate)
Zhou et al., Mol Cell Biol 2000, Jiang et al., Blood 2003, Minami et al., Immunity 1995
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SYK complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SYK)
(modification, collaborate)
Zhou et al., Mol Cell Biol 2000, Jiang et al., Blood 2003, Minami et al., Immunity 1995
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SYK complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SYK)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, activates)
Jiang et al., Blood 2003
Evidence: mutant phenotype
-
Reactome Reaction:
IL2
→
SYK
(reaction)
Zhou et al., Mol Cell Biol 2000, Minami et al., Immunity 1995
-
Reactome Reaction:
IL2
→
SYK
(indirect_complex)
Zhou et al., Mol Cell Biol 2000, Minami et al., Immunity 1995
Text-mined interactions from Literome
Kawakami et al., Proc Natl Acad Sci U S A 2000
:
Syk/Btk mediated PKCbetaI regulation is
involved in transcriptional activation of the
IL-2 and tumor necrosis factor alpha genes through the JNK pathway induced by FcepsilonRI stimulation
Slack et al., Eur J Immunol 2007
:
Syk dependent ERK activation
regulates IL-2 and IL-10 production by DC stimulated with zymosan
Minami et al., Immunity 1995
:
cDNA expression studies further revealed that this association is critical for the
IL-2 induced activation of
Syk PTK, which occurs primarily via the serine-rich region of the IL-2R beta chain, which is essential for proliferative signal transmission
Qin et al., FEBS Lett 1994
:
Interleukin 2 mediates
p72syk activation in peripheral blood lymphocytes ... The ability of
interleukin 2 (IL-2) to
stimulate p72syk activity in intact porcine peripheral blood lymphocytes was examined ... We demonstrated that
IL-2 activated
p72syk in a time- and dose dependent manner, for which its peak time and maximum responsive dose were 5 min and 100 U/ml, respectively