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GZMA — IL2

Text-mined interactions from Literome

Spitzer et al., Cell Immunol 1999 (Body Weight) : Interleukin 2 increased granzyme A protein expression independent of alcohol consumption ; however, this increase was associated with decreased enzyme activity
Zhou et al., Toxicological sciences : an official journal of the Society of Toxicology 2003 : Semiquantitative RT-PCR and real-time PCR analyses indicated that EtOH consumption inhibits the induction of perforin, granzyme A , and granzyme B in response to IL-2 ... Pyrrolidine dithiocarbamate ( PDTC ) and N-tosyl-L-phenylalanine chloromethyl ketone ( TPCK ) blocked NFkappaB and AP-1 binding activity in nuclear extracts of IL-2 stimulated NK cells in an EMSA and also inhibited the IL-2 induced expression of perforin, granzyme A , and granzyme B gene expression in enriched NK cells
Li et al., Zhonghua Xue Ye Xue Za Zhi 1997 : IL-2 and IFN-alpha alone or in combination had no effect on expression of granzyme A and B
Janas et al., J Immunol 2005 : We show in this study that IL-2 increased the expression of perforin and granzyme A , B, and C mRNA ; intracellular granzyme B protein levels ; and cytolytic function in a dose dependent manner during primary activation of murine CD8+ T cells in vitro ... This property of bcl-2 transgenic T cells also allowed the demonstration that induction of granzyme A , B, and C mRNA and granzyme B protein required exogenous IL-2 , whereas induction of perforin and IFN-gamma expression did not