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IL6 — TLR9

Text-mined interactions from Literome

Wagner et al., Curr Opin Microbiol 2002 (Bacterial Infections) : Interactions between CpG-DNA and TLR9 rapidly activate antigen presenting dendritic cells through the ancient Toll/IL-1-receptor signaling pathway to upregulate co-stimulatory molecules and to produce Th1 polarizing cytokines, such as interleukin-12 and interleukin-18
Klinman et al., Microbes Infect 2002 : ODNs of the `` K '' -type interact with Toll-like receptor 9 and induce monocytes to proliferate and secrete IL-6
Kurt-Jones et al., J Endotoxin Res 2004 : MEFs were highly responsive to TLR-ligand activation and secreted high levels of both IL-6 and MCP-1 in response to TLR ligands
Goral et al., J Immunol 2005 (Inflammation) : Furthermore, different TLR ligands stimulated IL-6 and TNF-alpha production via signaling pathways, which showed unique characteristics
Seki et al., Hepatology 2005 : However, TLR2 , 4 and 9, which recognize gram negative and -positive bacterial products, are not essential for NF-kappaB activation and IL-6 production after PH, which excludes a possible contribution of TLR2/TLR4 or TLR9 to MyD88 mediated pathways
Suliman et al., FASEB J 2005 : In wild-type ( Wt ) mice injected with heat inactivated E. coli, hepatic TLR4 and TLR2 proteins were up-regulated with TLR dependent increases in transcript levels for tumor necrosis factor ( TNF-alpha ), interleukin 6 , nitric oxide synthase-II ( iNOS ), and NADPH oxidase 2 (Nox2)
Zhang et al., EMBO J 2006 : We found that the serine phosphorylation was crucial for TLR induced interleukin 6 production and this process is regulated by TRAF6, a key adaptor molecule for the TLR pathway
Kuwata et al., Immunity 2006 (Colitis...) : IkappaBNS-deficient macrophages and dendritic cells show increased TLR mediated expression of genes such as IL-6 and IL-12p40, which are induced late after TLR stimulation
Kramer et al., J Leukoc Biol 2006 (Crohn Disease) : Moreover, they lack MDP induced enhancement of TLR mediated tumor necrosis factor alpha, interleukin (IL)-12 , and IL-10 production, which is observed in control DC with intact NOD2
Hayashi et al., J Gen Virol 2006 : Treatment of HCRFs transfected with HSV DNA with the TLR-9-inhibitory oligomer iODN, anti-TLR-3 antibody or phosphatidylinositol 3-kinase inhibitor indicated that IL-6 release from HCRFs was mediated by TLR-3 and -9 gene expression
Boyd et al., Cardiovasc Res 2006 (Myocarditis) : Ligand activation of TLR2, TLR4 and TLR5, but not TLR3, TLR7 or TLR9, resulted in cardiomyocyte expression of the inflammatory cytokine IL-6 , the chemokines KC and MIP-2, and the cell surface adhesion molecule ICAM-1
Shu et al., Clin Exp Immunol 2007 : natural killer ( NK ) 1.1 ( - ) CD11c ( + ) liver DC subsets ( conventional DCs, T cell receptor ( TcR ) beta ( - ) NK1.1 ( - ) CD11c ( + ) B220 ( - ) and plasmacytoid DCs, TcRbeta ( - ) NK1.1 ( - ) CD11c ( + ) B220 ( + ) ) efficiently endocytose dextran and produce significant levels of tumour necrosis factor (TNF)-alpha, interleukin (IL)-6 and IL-12 p40 in response to Toll-like receptor ( TLR ) ligands, with responses higher than splenic DCs
Batra et al., Am J Pathol 2007 : In WT preadipocytes the TLR responsiveness increased during maturation to adipocytes ; however, stimulation of ob/ob and db/db cells resulted in a 10- to 20-fold higher interleukin-6 production
Ivanov et al., Blood 2007 : CpG-ODN stimulates macrophages and dendritic cells to secrete HMGB1 ; in turn, extracellular HMGB1 accelerates the delivery of CpG-ODNs to its receptor, leading to a TLR9 dependent augmentation of IL-6 , IL-12, and TNFalpha secretion
Barr et al., Eur J Immunol 2007 : In this study, we investigated which mouse B cell subsets are the most potent cytokine producers, and examined the role of Toll-like receptors ( TLR ) in the control of secretion of IL-6 , IL-10, IL-12 and IFN-gamma by B cells
Taneichi et al., Clin Immunol 2008 (Agammaglobulinemia...) : Stimulation with TLR2, TLR4 and TLR7/8 ligands, as well as TLR3 ligand, resulted in significantly lower production of TNF-alpha, but neither IL-6 nor IL-12p70, by DCs from XLA patients in comparison to normal controls
Castillo et al., Nanomedicine (Lond) 2008 : Ag @ tiopronin nanoparticles were not proinflammatory agents, but remarkably they specifically impaired the IL-6 secretion mediated by TLR2, TLR2/6 , TLR3 or TLR9 stimulation in co-treatment experiments
Ospelt et al., Arthritis Rheum 2008 (Arthritis, Rheumatoid...) : Among the expressed TLRs, TLR-3 and TLR-4 were the most abundant in synovial fibroblasts, and stimulation of synovial fibroblasts with the TLR-3 ligand poly ( I-C ) led to the most pronounced increase in IL-6 , MMP-3, and MMP-13
Matsushita et al., Nature 2009 (Anemia...) : Macrophages from Zc3h12a ( -/- ) mice showed highly increased production of interleukin (IL)-6 and IL-12p40 ( also known as IL12b ), but not TNF, in response to TLR ligands
Zhu et al., J Biol Chem 2009 : Although pro-inflammatory cytokine and Ig production induced by CpG require TLR9 expression, we also found that SR-B1 negatively regulates TLR9 dependent production of interleukin-6, interleukin-10 , and IgM ... Although pro-inflammatory cytokine and Ig production induced by CpG require TLR9 expression, we also found that SR-B1 negatively regulates TLR9 dependent production of interleukin-6 , interleukin-10, and IgM
Rozková et al., Int J Cancer 2010 (Leukemia, Lymphocytic, Chronic, B-Cell) : TLR-7 and TLR-9 stimulation induces production of IL-6 and TNFalpha
Lee et al., J Parasitol 2010 : We also performed reverse transcriptase-polymerase chain reaction ( RT-PCR ) and flow cytometry to determine whether TLR and MUC expression is regulated by interferon (IFN)-gamma, interleukin-4 , or monoclonal antibodies ( mAbs ) against G. seoi 46 kDa antigen
Tang et al., Zhongguo Dang Dai Er Ke Za Zhi 2009 (Herpes Simplex...) : The production and release of IL-6 and IL-10 might be mediated by TLR2 and TLR9
Lanz et al., Stem Cells Dev 2010 (Encephalomyelitis, Autoimmune, Experimental) : This failure to catabolize trp is not due to defective TLR signaling as demonstrated by induction of interleukin 6 (IL-6) by TLR activation
Frazier et al., J Immunol 2009 (Escherichia coli Infections...) : MAPKs are crucial for TNF-alpha and IL-6 production by innate immune cells in response to TLR ligands
Suzuki et al., J Dent Res 2009 (Gingival Overgrowth) : In human gingival fibroblasts, cyclosporin alone did not induce evident inflammatory responses, but augmented the expression of CD54 and the production of interleukin (IL)-6 and IL-8 induced by TLR ligands, whereas phenytoin attenuated those responses
Lien et al., Proc Natl Acad Sci U S A 2010 (Splenomegaly) : The CD19 ( + ) Irf5 ( -/- ) B cells show a defect in Toll-like receptor (TLR) 7- and TLR9 induced IL-6 production, and the aged Irf5 ( -/- ) mice have decreased serum levels of natural antibodies ; however, the antigen-specific IgG1 primary response was already dependent in IRF-5 in young mice, although the IgM response was not
Fang et al., FEMS Immunol Med Microbiol 2010 (West Nile Fever) : Viral antigens were detected in WNV infected gammadelta T cells.WNV infection or toll-like receptor ( TLR ) agonist treatment of gammadelta T cells induced the production of IFN-gamma, tumor necrosis factor-alpha and IL-6 , which are known to promote DC maturation
Amu et al., Scand J Immunol 2010 : We found that CD25 ( + ) B cells secreted higher levels of IL-6 , IL-10 and INFgamma in response to different TLR-agonists , and were better at presenting alloantigen to CD4 ( + ) T cells
Dickie et al., Rheumatology (Oxford) 2010 (Autoimmune Diseases) : TLR9 induced IL-6 production was impaired in monocytes treated with vitamin D ( 3 ) compared with untreated cells
Han et al., Vet Microbiol 2010 : Involvement of TLR21 in baculovirus induced interleukin-12 gene expression in avian macrophage-like cell line HD11
Okuya et al., J Immunol 2010 : Recent studies have suggested that TLR9 signaling in early endosomes leads to IFN-alpha production by plasmacytoid dendritic cells ( pDCs ), whereas TLR9 signaling in late endosomes induces pDC maturation, IL-6 , and TNF-alpha secretion
Goeken et al., Lupus 2010 (Lupus Erythematosus, Systemic) : However, this enhanced potency was selective for TLR9 induced B-cell cycling and apoptosis protection while TLR9 induced IL-6 , an event that strongly depends on signaling via late endosomes, still required 10 times more Class R oligodeoxynucleotides
Piconi et al., AIDS 2010 (HIV Infections) : Activated T cells ( Ki67 ( + ) ), Treg lymphocytes ( CD4 ( + ) /CD25high/Foxp3+ ), divided into naive and activated cells based on PD1 expression, interleukin (IL)-10 and transforming growth factor ( TGF ) -beta production, annexin V, activation of caspases 8 and 9, Toll-like receptor (TLR)2 and TLR4 expression on immune cells, and plasma lipopolysaccharide (LPS) concentration were analyzed
Chung et al., J Infect Dis 2010 (Hepatitis C, Chronic) : Alloantigen presentation by monocytes isolated from HCV infected patients results in impaired production of interleukin 17 by naive CD4 ( + ) T cells in the presence of TLR ligands
Hunter et al., TheScientificWorldJournal 2010 (Peritonitis) : Selective inhibitors of Kv11.1 regulate IL-6 expression by macrophages in response to TLR/IL-1R ligands
Foldi et al., J Immunol 2010 : Jagged1 induction was augmented by IFN-?, was partially dependent on canonical TLR activated NF-?B and MAPK signaling pathways, and elevated Jagged1 expression augmented TLR induced IL-6 production
Chávez-Sánchez et al., Lipids in health and disease 2010 : The activation of CD14, TLR4 , and TLR2 by mmLDL induces IL-1ß, IL-6 , and IL-10 secretion in human monocytes and macrophages
Lavoie et al., J Infect Dis 2010 (Infant, Premature, Diseases...) : Preterm neonates had globally attenuated TLR stimulated interleukin (IL)-6 , interferon-a, and, to a lesser extent, tumor necrosis factor-a responses but demonstrated relative preservation of anti-inflammatory IL-10 responses in monocytes and dendritic cell subtypes
Agarwal et al., Arthritis Res Ther 2011 (Fibrosis...) : The ability of IFNa2 to regulate TLR induced interleukin (IL)-6 and CC chemokine ligand 2 production was also assessed
Vaquero et al., Hepatology 2011 : CONCLUSION : TLR-4 signaling contributes to IL-6 activation after PH, but the Tlr4 independent component appears sufficient for ensuring intact signaling downstream of IL-6
Tang et al., Contrib Nephrol 2011 (Diabetic Nephropathies...) : In human DN biopsies and PTEC, TLR4is upregulated and plays a permissive role in HG-induced IL-6 and CCL-2 overexpression and monocyte transmigration
Séité et al., J Autoimmun 2011 (Autoimmune Diseases) : As a result, IVIg suppresses TLR induced production of the proinflammatory IL-6 , but not that of the anti-inflammatory IL-10
Chung et al., J Viral Hepat 2011 (Hepatitis B...) : We previously showed that chronic exposure to the core antigen induces hyporesponsiveness to TLR ligands in antigen presenting cells via activation of TLR2 and that stimulation with TLR ligands results in impaired IL-6 production by peripheral blood monocytes from HCV infected patients
Farrar et al., FASEB J 2012 (Disease Models, Animal...) : Activation of TLR leads to activation of NF-?B and release of proinflammatory cytokines, such as IL-6 and TNF-a
Panda et al., J Reprod Immunol 2012 (Pre-Eclampsia) : The expression of TLR induced production of TNF-a, IFN-a, IL-6 , and IL-12 were measured by multicolor flow cytometry
Hanamsagar et al., Trends Immunol 2012 : TLR signaling triggers the transcriptional activation of pro-interleukin-1ß ( pro-IL-1ß ) and pro-IL-18 that are processed into their active forms by the inflammasome
Siggs et al., Blood 2012 : Neither the missense nor the null allele affected TLR induced secretion of IL-6
Zamora et al., Cytokine 2012 : Even though TLR-activation induced TNFa, IL-10 and IL-6 production, only recombinant TNFa was able to downregulate CD36
Kim et al., Microb Pathog 2013 : In addition, TLR4 was required for the optimal production of IL-6 , TNF-a, and IL-12 in BMDCs in response to A. baumannii
Li et al., eLife 2012 : A sequence containing 13 nucleotides near the active site of 23S rRNA ribozyme, which catalyzes peptide bond synthesis, was both necessary and sufficient to trigger TLR13 dependent interleukin-1ß production
Koblansky et al., Immunity 2013 (Genetic Predisposition to Disease...) : Toll-like receptor 11 ( TLR11 ) recognizes T. gondii profilin ( TgPRF ) and is required for interleukin-12 production and induction of immune responses that limit cyst burden in Toxoplasma gondii infected mice
Suwarti et al., Biochem Biophys Res Commun 2013 : Furthermore, we observed ODN-PD induced interleukin-6 (IL-6) through TLR9 in a CpG-sequence dependent manner in human peripheral blood mononuclear cells and B cells, whereas ODN-PTO induced IL-6 in a CpG-sequence independent manner
Yasuda et al., Int Immunol 2013 : IRF5 deficiency reduces IFN-a, IFN-ß and IL-6 production by Toll-like receptor 9 (TLR9)- and TLR7 stimulated DCs and reduces TLR7- and TLR9 induced IL-6 production by B cells to a similar extent in the two lines
Schamber-Reis et al., J Biol Chem 2013 (Disease Resistance...) : Altogether, our results indicate the redundant and essential role of nucleic acid sensing TLR3, TLR7 and TLR9 in inducing interleukin 12, development of a T1 response, and resistance to L. major infection in resistant C57BL/6 mice ... Altogether, our results indicate the redundant and essential role of nucleic acid sensing TLR3, TLR7 and TLR9 in inducing interleukin 12, development of a T1 response, and resistance to L. major infection in resistant C57BL/6 mice
Karrich et al., Blood 2013 : Although IL-21 did not affect TLR induced type I IFNs, IL-6 , and TNF-a nor expression of major-histocompatibility-complex class II or costimulatory molecules, IL-21 markedly increased expression of the serine protease granzyme B (GrB)
Giacomini et al., Eur J Immunol 2013 (Multiple Sclerosis, Relapsing-Remitting) : Furthermore, in MS-derived PBMCs, TLR7 mediated production of IL-6 and the ex vivo expression of B-cell activating factor of the TNF family, two crucial cytokines for B-cell differentiation and survival, were induced by IFN-ß
Liu et al., J Neurosci 2013 : In cultured neurons, TLR7 activation induced IL-6 and TNF-a expression through Myd88