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CD4 — IL6

Text-mined interactions from Literome

Borger et al., J Heart Lung Transplant 2002 : Depletion of CD4+ and/or CD8+ had no effect on the IL-6 and IL-8 production induced by the total CD2+ lymphocyte-population
Diehl et al., Mol Immunol 2002 : IL-6 activates transcription mediated by nuclear factor of activated T cells ( NFAT ) leading to production of IL-4 by nai ; ve CD4 ( + ) T cells and their differentiation into effector Th2 cells
Hata et al., J Clin Invest 2004 (Arthritis, Experimental...) : Thus, IL-6 , IL-1, TNF-alpha, and IL-10 play distinct roles in the development of SKG arthritis ; arthritogenic CD4 ( + ) T cells are not required to skew to either Th1 or Th2 ; and the appearance of rheumatoid factor is independent of joint inflammation
Kitamura et al., Immunity 2005 : Thus, IL-6-STAT3 mediated increase of cathepsin S activity reduces the MHCII alphabeta dimer, Ii, and H2-DM levels in DCs, and suppresses CD4 ( + ) T cell mediated immune responses
Pepe et al., Curr Pharm Des 2006 : This Th1 polarizing activity is mediated by interleukin-12 released by infected CDs in the presence of CD4 ( + ) cells
Ariga et al., Immunology 2007 : Using T-cell receptor ( TCR ) transgenic mice, we demonstrate that TCR stimulation of naive CD4 ( + ) T cells induces transient T-bet expression, interleukin (IL)-12 receptor beta2 up-regulation, and GATA-3 down-regulation, which leads to T helper ( Th ) 1 differentiation even when the cells are stimulated with peptide loaded I-A ( b ) -transfected Chinese hamster ovary cells in the absence of interferon-gamma (IFN-gamma) and IL-12
Schambach et al., Eur J Immunol 2007 : We now show that, in the context of TGF-beta signalling, all-trans retinoic acid ( ATRA ) leads to increased induction of CD4 ( + ) T cells expressing the Treg specification factor forkhead box protein P3 (FoxP3) and decreased frequency of cells expressing IL-17, even in the presence of IL-6
Li et al., J Neuroimmunol 2008 (Genetic Predisposition to Disease...) : EAMG resistance was associated with reduced lymph node cell IL-6 and IL-10 production and increased CD4 ( + ) CD25 ( + ) cell ratios in lymph nodes
Longhi et al., PLoS Pathog 2008 (Orthomyxoviridae Infections) : Specifically, we find that CD4+ but not CD8+ T cell memory is critically dependent upon IL-6
Dienz et al., Clin Immunol 2009 : The effects of IL-6 on CD4 T cell responses ... This review highlights the variety of ways in which IL-6 affects CD4 effector functions and how this may contribute to different types of diseases
Lyakh et al., Immunol Rev 2008 : IL-23, IL-6 , transforming growth factor ( TGF-beta1 ), and IL-1beta in supernatants from activated human DCs induce human naive CD4 ( + ) T cells to produce IL-17
Qin et al., J Immunol 2009 : In mice with a dominant negative form of TGF-beta receptor II and impaired TGF-beta signaling, IL-6 induced CD4 ( + ) T cell expression of SOCS3 is higher whereas STAT3 activation is lower compared with wild-type B6 CD4 ( + ) T cells
El-behi et al., J Immunol 2009 (Encephalomyelitis, Autoimmune, Experimental) : IL-27 counters the effect of TGF-beta+IL-6 on naive CD4 ( + ) T cells, resulting in near complete inhibition of de novo Th17 development
Cash et al., J Rheumatol 2010 (Inflammation...) : The absence of IL-6 resulted in significant reduction of infiltrating macrophages in the kidney ( p < 0.05 ), a decrease in renal IgG and C3 deposition, and a reduction of CD4+ and CD8+ lymphocytes
Zhang et al., J Leukoc Biol 2010 : CpG treated, CD4-8- DCOVA secreting IL-6/IL-15 induced IFN-gamma/IL-17-secreting/T-bet- and ROR-gammat expressing CD4+ Th1/Th17, whereas LPS treated CD4-8- DCOVA stimulated IFN-gamma-secreting/T-bet expressing CD4+ Th1 responses
Guo et al., Zhongguo Shi Yan Xue Ye Xue Za Zhi 2011 : Test group in which CD4 ( + ) T cells ( 1 x 10 ( 6 ) /ml ) were stimulated by human recombined IL-6 ( 20 ng/ml ) for 4 days ; control group in which CD4 ( + ) T cells did not stimulated by IL-6
Tormo et al., Cytokine 2012 : CD4 T cell stimulation with IL-6 induces the synthesis of CIS, which is encoded by a gene known to be regulated by STAT5
Xu et al., Frontiers in immunology 2012 : We developed a dual cytokine enzyme linked immunocell spot assay, the ?-6 Spot, using CD4 T cell IFN-? and IL-6 responses and found that it discriminated emphysema with 90 % sensitivity
Narita et al., J Immunol 2013 (Neoplasms) : In this study, we initially found that IL-6 , one of the cachectic factors, suppressed CD4 ( + ) T cell mediated immunity through downregulation of MHC class II by enhanced arginase activity of dendritic cells ( DC ) in tumor bearing mice
Vandergeeten et al., Blood 2013 (HIV Infections) : When administered to HIV infected subjects receiving suppressive ART, interleukin-7 (IL-7) increases the number of CD4 ( + ) T cells by promoting their survival and proliferation
Taimi et al., J Leukoc Biol 1994 (Leukemia, Promyelocytic, Acute) : Involvement of CD4 in interleukin-6 secretion by U937 monocytic cells stimulated with the lectin jacalin ... This jacalin induced IL-6 production was inhibited by agents interacting with CD4 ( anti-CD4 mAbs and HIV recombinant gp120 ) or by recombinant soluble CD4
Suzuki et al., J Virol 1999 : Among them, interleukin-12 (IL-12) and IL-4 induce naive CD4 ( + ) T cells to become T-helper 1 ( Th1 ) or Th2 cells, respectively