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LEP — PRKAR2B
Text-mined interactions from Literome
Yamagishi et al., J Biol Chem 2001
:
Leptin activated
PKA , and the effects of
leptin were
inhibited by the cAMP antagonist Rp-cAMPS
Ke et al., Biochem Biophys Res Commun 2003
(Body Weight) :
Overexpression of
leptin in transgenic mice
leads to decreased basal lipolysis,
PKA activity, and perilipin levels
Szkudelski et al., Physiol Res 2005
:
Inhibition of
protein kinase A (PKA) by H-89 ( 50 micromol/l ) slightly
enhanced leptin release stimulated by glucose and leucine but not by alanine ... Moreover, it has also been shown that inhibition of
PKA evokes the opposite effect and
enhances leptin release
Sirotkin et al., Physiol Res 2008
:
The aim of our in vitro studies was to understand the
role of
leptin in controlling proliferation, apoptosis, and
protein kinase A (PKA) in human ovarian cells ... We analyzed the in vitro
effects of
leptin ( 0, 1, 10 or 100 ng/ml ) on the accumulation of proliferation related peptides ( PCNA, cyclin B1 ), apoptosis associated peptide ( Bax ) and the intracellular signaling molecule
PKA in cultured human granulosa cells using immunocytochemistry and Western immunoblotting ... It was observed that
leptin stimulated in a dose dependent manner the accumulation of PCNA ( at doses 1-100 ng/ml ), cyclin B1 ( at doses 10 or 100 ng/ml ), Bax ( at doses 10 or 100 ng/ml ) and
PKA ( at doses 1-100 ng/ml ) in cultured human ovarian cells
Sirotkin et al., Comp Biochem Physiol A Mol Integr Physiol 2007
:
Finally,
leptin inhibited expression of MAPK/ERK1,2 and CDK/p34 and
stimulated expression of
PKA
Yang et al., PloS one 2008
:
cAMP/PKA regulates osteogenesis, adipogenesis and ratio of RANKL/OPG mRNA expression in mesenchymal stem cells by suppressing
leptin ... All these effects are mediated by the cAMP/PKA/CREB pathway by suppressing
leptin , and may
contribute to
PKA stimulators induced in vivo bone loss in developing zebrafish
Maeda et al., J Biochem 2009
:
Finally,
PKA inhibited
leptin gene transcription without new protein synthesis
Mehebik-Mojaat et al., J Cell Biochem 2009
(Insulin Resistance) :
When
leptin signaling was
blocked by
PKA inhibitors, insulin induced NOS activity and NOS III phosphorylation at Ser ( 1179 ) was observed
Maymó et al., PloS one 2012
(MAP Kinase Signaling System) :
We found that specific
PKA inhibition by H89
caused a significant increase of hCG
leptin induction, suggesting that probably high cAMP levels might inhibit hCG effect ... In this work, we demonstrated that hCG
leptin induction through the MAPK signaling pathway is
inhibited by
PKA