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ANGPT4 — HIF1A
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
ANGPT4
→
HIF1A
(increases, ANGPT4 Activity)
Yamakawa et al., Circ Res 2003*
Evidence: In primary human endothelial cells, hypoxia, desferrioxamine, or infection with Ad2/HIF-1alpha/VP16, an adenoviral vector encoding a constitutively stable hybrid form of HIF-1alpha, increased the mRNA and protein levels of VEGF, angiopoietin-2 (Ang-2), and angiopoietin-4 (Ang-4)
-
OpenBEL Selventa BEL large corpus:
ANGPT4
→
HIF1A
(increases, ANGPT4 Activity)
Yamakawa et al., Circ Res 2003*
Evidence: Ang-4 was also induced by hypoxia or Ad2/HIF-1alpha/VP16 in human cardiac cells
Text-mined interactions from Literome
Yamakawa et al., Circ Res 2003
:
Ang-4 was also
induced by hypoxia or
Ad2/HIF-1alpha/VP16 in human cardiac cells, whereas Ang-1 expression remained unchanged
Yamakawa et al., American journal of physiology. Renal physiology 2004
(Adenocarcinoma, Clear Cell...) :
In RPTE cells,
angiopoietin-4 (Ang-4) expression was selectively
induced by hypoxia or by expression of a hybrid form of
HIF-1alpha
Abaci et al., Am J Physiol Cell Physiol 2010
:
Corresponding upregulation of VEGF,
ANGPT2 , and GLUT-1 was observed in
response to
HIF-1alpha accumulation, whereas upregulation of ANGPT1 was detected only in hESCs and iPSCs