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BRCA1 — DDB2

Text-mined interactions from Literome

Takimoto et al., Cancer Biol Ther 2002 : BRCA1 enhances p53 binding to the DDB2 promoter in vivo as well as p53 dependent transactivation of DDB2 promoter-reporter constructs through a classical p53 DNA responsive element
Hartman et al., Nat Genet 2002 (Breast Neoplasms) : Here we show that BRCA1 specifically enhances the GGR pathway, independent of p53, and can induce p53 independent expression of the NER genes XPC, DDB2 , and GADD45
El-Deiry et al., Cancer Biol Ther 2002 (Breast Neoplasms...) : There is some controversy regarding the precise mechanism of upregulation of XPE DDB2 or XPC by BRCA1 , with some evidence suggesting that p53 is involved in their regulation
Navaraj et al., Cancer Biol Ther 2005 (Breast Neoplasms...) : We previously showed that the breast and ovarian cancer susceptibility gene product BRCA1 , through p53, upregulates expression of the XPE gene DDB2 encoding the nucleotide excision repair protein p 48