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FUT1 — TNF
Text-mined interactions from Literome
Saile et al., Eur J Cell Biol 2001
:
The aim of this study was to investigate the possible mechanisms responsible for the spontaneous apoptosis and for the anti-apoptotic
effect of TGF-beta and
TNF-alpha on activated
HSC
Li et al., Yao Xue Xue Bao 2001
:
Adhesion molecular VCAM-1 and ICAM-1 protein and mRNA ( rather than ICAM-1 ) expression in
HSC induced by
TNF-alpha ( 50 U.mL-1 ) were inhibited significantly by hydrocortisone at 1 x 10 ( -6 ) -10 ( -5 ) mol.L-1
Hou et al., Yao Xue Xue Bao 2001
:
To study the effects of isorhapotigenin ( Iso ) on interleukin-8 (IL-8) production and mRNA expression in normal
human synovial cells (HSC) induced with
TNF alpha ... The further study indicated that Iso at the concentrations of 1 x 10 ( -6 ) mol.L-1 to 1 x 10 ( -5 ) mol.L-1 inhibited IL-8 mRNA expression in
HSC induced with
TNF alpha ( 0.25 U.mL-1 )
Sugino et al., J Gastroenterol Hepatol 2008
(Body Weight...) :
MCD mice developed steatohepatitis accompanied by mild fibrosis with an increase in lipid peroxidation,
hepatic stellate cell (HSC) activation , and the augmented mRNA expression of
tumor necrosis factor-alpha , transforming growth factor-beta1 and procollagen alpha1 ( I )
Su et al., Cytokine 2010
(Endotoxemia) :
The
effect of
HSC70 on
TNF-alpha was less robust than endotoxin preconditioning ( 79.7 % and 75.0 % reduction in TNF-alpha levels in plasma and heart tissue, respectively ) ; however, HSC70 and endotoxin preconditioning had comparable effects on ICAM-1 levels in heart tissue
Fujiwara et al., J Am Coll Surg 2013
(Pancreatic Neoplasms) :
In vitro, we assessed that
FUT175 inhibited both
TNF-a- and gemcitabine induced NF-?B activation and enhanced apoptosis in human pancreatic cancer cell lines ( MIAPaCa-2 and AsPC-1 ) ... In vitro,
FUT175 inhibited both
TNF-a- and gemcitabine induced NF-?B activation and enhanced induction of apoptosis
Osawa et al., PloS one 2013
:
However, the
roles of
TNF-a on
hepatic stellate cell (HSC) activation and liver fibrosis are complicated and remain controversial
Liu et al., J Pathol 2013
(Disease Models, Animal...) :
JTE-013 or S1PR2-siRNA attenuated the effect of HPPCn on
HSC activation
induced by
tumour necrosis factor-a (TNF-a)
Schuettpelz et al., Frontiers in immunology 2013
:
Type I and II interferons,
tumor necrosis factor , and lipopolysaccharide (LPS) directly
stimulate HSC proliferation and differentiation, thereby increasing the short-term output of mature effector leukocytes