Gene interactions and pathways from curated databases and text-mining

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DEFA1 — TNF

Text-mined interactions from Literome

Trincavelli et al., J Neurochem 2004 (Astrocytoma) : This event was completely prevented by the selective A2B AR antagonist MRS 1706 and required the presence of TNF-alpha
Kang et al., Circ Res 2006 (Heart Failure...) : Blocking brain mineralocorticoid receptors (MRs) reduces the high circulating levels of tumor necrosis factor (TNF)-alpha in heart failure ( HF ) rats
Yang et al., Immunol Cell Biol 2010 : The A2b receptor antagonist MRS1754 was able to increase the production of IL-12p70 and TNF-alpha by hypoxic mDCs and elevate the amount of Th1 cytokine IFN-gamma production in a mDCs-T-cell co-culture system