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MYC — PLD4
Text-mined interactions from Literome
Chen et al., Oncogene 2003
(Adenocarcinoma...) :
Elevated
PLD activity in MCF-7 cells also caused rapamycin resistance for S6 kinase phosphorylation and serum
induced Myc expression
Rodrik et al., FEBS Lett 2006
(Breast Neoplasms) :
We report here that estrogen- and
PLD induced increases in
Myc expression are due to reduced turnover of Myc protein ... Estrogen and
PLD suppressed phosphorylation of
Myc at Thr58 -- a site that targets Myc for degradation by the proteasome