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GALP — LEP
Text-mined interactions from Literome
Krasnow et al., Endocrinology 2003
(Body Weight) :
GALP neurons in the arcuate nucleus coexpress leptin receptors, and
GALP mRNA expression is
up-regulated by
leptin
Kumano et al., Endocrinology 2003
(Disease Models, Animal...) :
The result supports the hypothesis that the hypothalamic
GALP gene expression is
controlled by
leptin signals and suggests possible involvement of GALP in the reproductive abnormalities of the Zucker obese rat
Hansen et al., Endocrinology 2003
(Body Weight...) :
Galanin-like peptide (GALP) , a recently described hypothalamic neuropeptide, is
up-regulated by
leptin and has anorectic effects in the mouse ... We postulated that
GALP mediates effects of
leptin upon metabolism ... These observations suggest that
leptin 's activation of the sympathetic nervous system, and ultimately thermogenesis, may be partially
mediated by
GALP through a melanocortin independent mechanism
Seth et al., Endocrinology 2004
:
Galanin-like peptide stimulates the release of gonadotropin releasing hormone in vitro and may
mediate the effects of
leptin on the hypothalamo-pituitary-gonadal axis
Stoyanovitch et al., Diabetes 2005
(Body Weight...) :
Galanin-like peptide (GALP) is expressed in the hypothalamic arcuate nucleus and is
regulated by
leptin and insulin
Rich et al., Physiol Behav 2007
(Body Weight) :
After 2 weeks, GALP infusion had no significant effect on the onset of puberty, percent body fat, nor plasma levels of insulin, FSH or gonadal steroids in either sex ; however,
GALP did significantly ( p < 0.05 )
increase plasma levels of LH and
leptin in male but not female rats and increased plasma growth hormone (GH) in both sexes