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NFKB1 — PKD3
Text-mined interactions from Literome
Storz et al., EMBO J 2003
:
PKD activates
NF-kappaB through the IKK complex and more specifically, IKKbeta, leading to I(kappa)B(alpha) degradation
Storz et al., Mol Cell Biol 2004
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We also show that other PKCs, including PKCepsilon and PKCzeta, do not participate in
PKD activation or
NF-kappaB induction
Storz et al., Mol Pharmacol 2004
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Resveratrol, a potent antioxidant, blocks both
PKD activation and
NF-kappaB induction
Arnold et al., Mol Cell Biol 2005
:
Upon T-cell receptor stimulation,
PKD robustly augments HPK1 kinase activity in Jurkat T cells and
enhances HPK1-driven SAPK/JNK and
NF-kappaB activation ; conversely, antisense down-regulation of PKD results in reduced HPK1 activity