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EIF2AK2 — STAT1
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
STAT1
—
EIF2AK2
(physical association, affinity chromatography technology)
Wong et al., EMBO J 1997*
-
IRef Biogrid Interaction:
STAT1
—
EIF2AK2
(direct interaction, pull down)
Wong et al., J Biol Chem 2001*
-
IRef Hprd Interaction:
EIF2AK2
—
STAT1
(in vivo)
Wong et al., J Biol Chem 2001*, Wong et al., EMBO J 1997*
-
IRef Hprd Interaction:
EIF2AK2
—
STAT1
(in vitro)
Wong et al., J Biol Chem 2001*, Wong et al., EMBO J 1997*
-
IRef Ophid Interaction:
EIF2AK2
—
STAT1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Wong et al., J Biol Chem 2001
:
These data substantiate our previous findings on the inhibitory
effects of
PKR on
STAT1 and implicate STAT1 in translational control through the modulation of PKR activation and eIF-2alpha phosphorylation
Härle et al., Virology 2001
:
Viral lytic gene transcript and viral protein levels were lower in IFN-beta- versus IFN-alpha 2-transfected cells, which coincided with elevated
PKR and OAS transcript levels and
increased total STAT1 and phosphorylated
STAT1 ( Y701 ) protein levels in the IFN-beta transfected cells
Baran-Marszak et al., Blood 2004
:
Expression of
STAT1beta inhibited the phosphorylation, the DNA binding activity, and the transcriptional activity of STAT1alpha, as well as the expression of STAT1alpha target genes such as p21WAF1/CIP1, TAP1, IRF1, and
PKR
Wang et al., J Biol Chem 2006
:
The catalytic activity of the eukaryotic initiation factor-2alpha kinase
PKR is
required to negatively regulate
Stat1 and Stat3 via activation of the T-cell protein-tyrosine phosphatase
Kårehed et al., Mol Immunol 2007
:
We find that the serine 727 phosphorylation of
Stat1 , required for full IFN-gamma induced FcgammaRI promoter activity, is
dependent on
PKR ... Our results suggest that IFN-gamma induced increase of FcgammaRI expression requires the integration of two signalling events :
PKR dependent
Stat1 serine 727 phosphorylation, and activation of NFkappaB
Yoshida et al., Exp Cell Res 2009
:
PKR mediated degradation of
STAT1 regulates osteoblast differentiation ... The expression and degradation of
STAT1 protein were
regulated by
PKR in a SLIM dependent pathway
Ruuska et al., Arthritis Rheum 2012
:
Specific inhibitors were added in cell culture to study the
role of
PKR and p38 in
STAT-1 phosphorylation ... In addition, phosphorylation of
STAT-1 was
dependent on
PKR
Ruuska et al., PloS one 2013
:
Specific inhibitors were employed to study the
role of
PKR in
STAT-1 phosphorylation ... Interestingly,
STAT-1 serine 727 phosphorylation is partly
dependent on
PKR
Handy et al., Gene 2013
:
PKR activation induced by antiproliferative agent heparin
leads to phosphorylation of
STAT1 on serine 727, which is essential for the cell cycle block