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PI3 — PTGS2
Text-mined interactions from Literome
Barry et al., J Biol Chem 1999
:
In U-937 cells, MP-induced
COX-2 expression and eicosanoid formation is
prevented by pharmacological inhibitors of protein kinase C ( PKC ),
PI 3-kinase , mitogen activated protein kinase ( MAPK ) /extracellular signal regulated kinase, and p38 kinase
Weaver et al., Gastroenterology 2001
:
We investigated the regulatory
role of
PI 3-kinase on
COX-2 expression in colonic epithelial cells ... The
PI 3-kinase inhibitor wortmannin
up-regulated induced
COX-2 expression in a concentration dependent manner in both HT-29 and Caco-2 cells ...
COX-2 is negatively
regulated by
PI 3-kinase ; we propose that the inhibitory effect of IL-4 and IL-13 is mediated via a PI 3-kinase dependent pathway
Ashida et al., Exp Dermatol 2003
(MAP Kinase Signaling System) :
Inhibitors of MEK, p38 MAP kinase and
PI3-kinase ,
suppressed the induction of
COX-2 expression by UV
Chang et al., Mol Pharmacol 2004
:
In this study, we explore the
role of Ras,
phosphoinositide-3-OH-kinase (PI3K) , Akt, and transcription factor nuclear factor-kappaB (NF-kappaB) in YC-1 induced
COX-2 expression in A549 cells
Takeda et al., J Dermatol 2004
(Skin Neoplasms) :
The
PI3 kinase inhibitor LY294002
reduced COX-2 expression in HSC-5 cells and, contrary to our expectation, the phosphorylation of Akt was significantly decreased
Chen et al., Mol Biol Cell 2005
:
MG132 induced DNA binding activity of C/EBPdelta, but not C/EBPbeta was regulated by p38,
PI3K , Src, and protein kinase C. Small interfering RNA of C/EBPdelta
suppressed COX-2 expression, further strengthening the role of C/EBPdelta in COX-2 gene transcription
RodrÃguez-Barbero et al., Kidney Int 2006
:
We designed studies to determine ( 1 ) whether TGF-beta1 stimulates COX-2 expression in primary HMC, ( 2 ) whether mitogen activated protein kinase ( MAPK ) and
phosphatidylinositol 3-kinase (PI3K) cascades are
involved in TGF-beta1 induced
COX-2 expression, and ( 3 ) whether prostaglandin ( PG ) E2 synthesis is affected by TGF-beta1 and MAP kinases and PI3K activation
Liu et al., Mol Immunol 2007
:
Further studies show that the triptolide mediated inhibitory effects of LPS induced activation of
phosphatidylinositol-3 kinase (PI3-K)/Akt and nuclear NF-kappaB activation are
involved in down-regulation of
COX-2 and CCR7 expression resulting in impaired migration to secondary lymphoid organs of DC
de Oliveira et al., Glia 2008
:
In contrast to other reports, LPS induced mPGES-1 synthesis was not invariably coupled to the synthesis of COX-2, since inhibition of
PI-3K with LY294002 decreased mPGES-1 but
increased COX-2 levels
Sun et al., Toxicol Appl Pharmacol 2008
:
While investigating whether
phosphatidylinositol 3 kinase (PI3K) plays a role in corticosterone ( CT ) -induced
COX-2 , we found that LY294002 ( LY29 ) but not wortmannin ( WM ) attenuates CT from inducing COX-2 gene expression
Husvik et al., Eur J Oral Sci 2009
(Carcinoma, Basosquamous...) :
Surprisingly, inhibition of
phosphoinositide-3 kinase (PI3K) increased EGF induced
COX-2 expression in the basaloid OSCC cell line ( C12 ), suggesting a PI3K controlled, inhibitory COX-2 regulating pathway
Lin et al., Int Immunopharmacol 2010
:
On the other hand, PGN induced iNOS and
COX-2 up-regulation were
attenuated by
PI3-kinase inhibitors ( LY294002 and wortmannin ), and an AKT inhibitor
Frey et al., Lab Invest 2010
(Colonic Neoplasms) :
ErbB4 stimulated
COX-2 induction was associated with an increase in mRNA half-life and was
blocked by inhibition of Src,
phosphatidylinositol (PI) 3-kinase , or epidermal growth factor receptor (EGFR)
Hirota et al., Am J Physiol Gastrointest Liver Physiol 2012
:
However, inhibition of either Src tyrosine kinase signaling by PP2, Rho kinase signaling by Y27632, or
phosphatidylinositol 3 (PI3) kinase signaling by LY294002
prevented 2fLI induced
COX-2 expression
Cho et al., Cell Physiol Biochem 2012
(MAP Kinase Signaling System) :
Among the signaling components of FceRI, Fyn,
PI 3-kinase , Akt, and p38 MAPK positively
mediated the
COX-2 expression
Huang et al., Toxicol Appl Pharmacol 2013
(Inflammation) :
We also found that LTA induced iNOS and
COX-2 up-regulation were
attenuated by p38, JNK, and
PI3-kinase inhibitors