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CXCL12 — TNMD
Text-mined interactions from Literome
Ding et al., J Leukoc Biol 2000
:
Monocyte chemotactic protein-1 (MCP-1), RANTES, and macrophage inflammatory protein-1alpha ( MIP-1alpha ) induced TEM by memory T cells, while
stromal cell derived factor-1 (SDF-1) induced
TEM by both naive and memory T cells
Kukreja et al., Cancer Res 2005
(Bone Neoplasms...) :
SDF-1alpha increased PC-3 cell adhesion to the human umbilical vein endothelial cell monolayer and
enhanced TEM , which was abrogated with anti-CXCR4 monoclonal antibody ( mAb )
Zabel et al., J Immunol 2009
:
Importantly, although CXCL11 is unable to stimulate directly the migration of these cells, it acts as a potent antagonist of their
CXCL12 induced
TEM
Lee et al., J Leukoc Biol 2009
:
Moreover,
CXCL12 induced
retro-TEM was inhibited by PI3K antagonism and cAMP agonism
Zabel et al., Molecular cancer 2011
(Lymphoma, B-Cell...) :
In this study, we set out to assess the potential
stimulation by
CXCL12 of tumor cell
TEM towards other chemokines and whether CXCR7 might be able to regulate such effects ... This CXCL12 potentiated
TEM was
inhibited by the second CXCR7 chemokine ligand,
CXCL11 , as well as CXCR7-specific small molecule antagonists and antibodies
Lin et al., Eur J Immunol 1998
:
These cells exhibited potent chemotaxis and
TEM responses to the CC chemokines macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, RANTES, and monocyte chemotactic protein-3, and weak responses to the CC chemokine MIP-3beta and the CXC chemokine
stromal cell derived factor (SDF)-1alpha