Natarajan et al., Am J Physiol Heart Circ Physiol 2007
(Anoxia...) :
Our results show that HIF-1 activation induced both pharmacologically by the prolyl hydroxylase inhibitor dimethyloxallyl glycine and via small interfering RNA ( siRNA ) -mediated prolyl-4 hydroxylase-2 (P4HA2) gene silencing significantly attenuated tumor necrosis factor-alpha induced chemokine ( KC and LIX ) and ICAM-1 expression in cardiomyocytes
Lin et al., Invest Ophthalmol Vis Sci 2012
(Anoxia...) :
In the laser induced CNV model, however, the disruption of HIF-1a in the RPE attenuated the over expression of VEGF and the intercellular adhesion molecule 1 ( ICAM-1 ), and reduced vascular leakage and CNV area