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POT1 — RASGRP3
Text-mined interactions from Literome
Regier et al., Proc Natl Acad Sci U S A 2005
(Neoplasms, Experimental) :
In addition to activating Ras,
RasGRP3 also
activates Rap1 , which in some cases can antagonize the function of Ras ... In addition to activating Ras,
RasGRP3 also
activates Rap1 , which in some cases can antagonize the function of Ras
Ikuta et al., Cancer Res 2008
(Dermatitis, Contact...) :
Experiments using small interfering RNA mediated knockdown indicate that this activation is mediated by
Rap1 , which is
activated by a TPA-responsive guanine nucleotide exchange factor
RasGRP3
Takino et al., Cell Adh Migr 2013
:
Furthermore,
RasGRP2 overexpression
increased Rap1 activation and cell-matrix adhesion in ECV304 cells