Bongalon et al., J Vasc Res 2004
:
Inhibition of ERK MAPKs ( U-0126, 10 muM ) or p38 MAPK ( PD-169316, 10 muM ), but not PI3Ks ( LY-294002, 50 muM ), reduced LIMK2 and cofilin gene expression stimulated by PDGF or IL-1beta
Hirayama et al., J Leukoc Biol 2007
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These results suggested that unphosphorylated cofilin plays a critical role in leukocyte chemotaxis and that PI-3K is involved in the control of the phosphorylation/dephosphorylation cycle of cofilin