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PGF — PLA2G4A

Text-mined interactions from Literome

Godkin et al., Reproductive biology and endocrinology : RB&E 2008 : Results from this study demonstrate that PGE2 and PGF2-alpha production by BEND cells is mediated by the activity and expression of PLA2G4A
Ishida et al., Am J Physiol Heart Circ Physiol 2011 (Diabetes Mellitus, Type 2...) : In arteries from GK rats ( vs. those from Wistar rats ), 1 ) ATP- and UTP induced contractions, which were blocked by the nonselective P2 antagonist suramin, were enhanced, and these enhancements were suppressed by endothelial denudation, by cyclooxygenase (COX) inhibitors, or by a cytosolic phospholipase A ( 2 ) ( cPLA(2) ) inhibitor ; 2 ) both nucleotides induced increased release of PGE ( 2 ) and PGF ( 2a ) ; 3 ) nucleotide stimulated cPLA(2) phosphorylations were increased ; 4 ) COX-1 and COX-2 expressions were increased ; and 5 ) neither P2Y2 nor P2Y6 receptor expression differed, but P2Y4 receptor expression was decreased ... Mesenteric arteries from GK rats treated with losartan exhibited ( vs. untreated GK ) 1 ) reduced nucleotide induced contractions, 2 ) suppressed UTP induced release of PGE ( 2 ) and PGF ( 2a ), 3 ) suppressed UTP stimulated cPLA(2) phosphorylation, 4 ) normalized expressions of COX-2 and P2Y4 receptors, and 5 ) reduced superoxide generation
Kan et al., Mol Pharmacol 1996 : These data suggest that ACh stimulates prostacyclin synthesis by activation of cPLA2 in a PKC independent mechanism and that both cPLA2 translocation to nuclear envelope and phosphorylation by MAPK are required for ACh induced 6-keto-PGF1 alpha synthesis in CEC