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EDN1 — MAPK6
Text-mined interactions from Literome
El-Mowafy et al., FEBS Lett 1999
:
Endothelin-1 (ET-1) , a primary antecedent in coronary heart diseases,
enhanced MAPK activity, phosphorylation and nuclear translocation in a concentration-responsive but RSVL-sensitive manner
Ueyama et al., Mol Cell Biochem 1999
(Cardiomegaly) :
Endothelin-1 activates p38
mitogen activated protein kinase via endothelin-A receptor in rat myocardial cells
Kawamura et al., Am J Physiol 1999
:
We previously reported that
endothelin-1 (ET-1) activates p42/p44
mitogen activated protein ( MAP ) kinase in osteoblast-like MC3T3-E1 cells and consequently induces synthesis of interleukin-6
Dulin et al., J Biol Chem 2000
(Calcium Signaling) :
Both RGS3 and RGS3T bound to endogenous Galpha ( q/11 ) and inhibited
endothelin-1 stimulated calcium mobilization and
mitogen activated protein kinase activity to a similar extent
Inui et al., Life Sci 2000
:
Effect of
endothelin-1 ( 1-31 ) on p38
mitogen activated protein kinase in cultured human mesangial cells
Kawanabe et al., Eur J Pharmacol 2001
(Neuroblastoma) :
Endothelin-1 activated
mitogen activated protein kinase in B103 cells
Kusano et al., Kidney Blood Press Res 2001
:
We investigated whether rHuEPO has modulative effects on the
endothelin-1 (ET-1) induced elevation of cytosolic free calcium concentration ( [ Ca2+ ] i ) and
mitogen activated protein ( MAP ) kinase activation in vascular smooth muscle cells ( VSMC )
Tokuda et al., Prostaglandins Leukot Essent Fatty Acids 2002
:
We previously showed that prostaglandin F ( 2alpha ) ( PGF ( 2alpha ) ) and
endothelin-1 (ET-1) induce interleukin (IL)-6 through the activation of protein kinase C-dependent p44/p42
mitogen activated protein ( MAP ) kinase in osteoblast-like MC3T3-E1 cells
Rachdaoui et al., Am J Physiol Endocrinol Metab 2003
:
In contrast,
activation of p38
MAPK by
endothelin-1 was not affected by chronic ethanol exposure
Tokuda et al., Eur J Endocrinol 2003
:
We have reported that
endothelin-1 (ET-1) activates p38
mitogen activated protein ( MAP ) kinase through protein kinase C in osteoblast-like MC3T3-E1 cells, and that p38 MAP kinase plays a role in the ET-1 induced heat shock protein 27 (HSP27)
Zubkov et al., J Cardiovasc Pharmacol 2004
:
The following results were observed : ( 1 ) endothelin-1 produced phosphorylation of MAPK and RhoA and contraction by activation of endothelin-A but not endothelin-B receptors ; ( 2 ) MAPK inhibitors, PD 98059 and U0126, PTK inhibitor, genistein, Src kinase inhibitor, damnacanthal, and Janus tyrosine kinase ( JAK2 ) inhibitor, AG-490, abolished
endothelin-1 induced contraction and
MAPK immunoreactivity ; ( 3 ) PTK inhibitor, staurosporine, and phosphatidylinositol 3-kinase (PI- 3K) inhibitor wortmannin abolished endothelin-1 induced contraction but not MAPK immunoreactivity ; ( 4 ) Rho-kinase inhibitor, Y-27632, reduced endothelin-1 induced contraction ; ( 5 ) PI-3K inhibitor, wortmannin, but not PKC and PTK inhibitors, reduced endothelin-1 induced RhoA activation ; ( 6 ) endothelin-1 increased the level of myosin light chain ( MLC ) phosphorylation, and Rho-kinase inhibitor, Y-27632, reduced the effect of endothelin- 1 on MLC phosphorylation
Irukayama-Tomobe et al., J Cardiovasc Pharmacol 2004
(Hypertrophy) :
Activation of peroxisome proliferator activated receptor-alpha decreases
endothelin-1 induced p38
mitogen activated protein kinase activation in cardiomyocytes
Patzak et al., Am J Physiol Regul Integr Comp Physiol 2007
:
However, phosphorylation of p38
MAPK induced by norepinephrine or
endothelin-1 was reduced in vessels treated with Ado, whereas 20-kDa myosin light chain was unchanged
Nilsson et al., Eur J Pharmacol 2008
(Cardiovascular Diseases) :
We hypothesize that protein kinase C ( PKC ) and mitogen activated kinases (
MAPK ) are
involved in the regulation of
endothelin receptors
Eriksson et al., J Ethnopharmacol 2008
:
We also demonstrate that Panax ginseng,
endothelin-3 (ET-3) and alpha-melanocyte stimulating hormone ( MSH )
stimulate an activation of
mitogen activated protein kinase ( MAPK )
Nilsson et al., BMC cardiovascular disorders 2008
:
The
involvement of PKC and
MAPK in the
endothelin receptor regulation was examined by culture in the presence of antagonists
Chen et al., BMC cell biology 2009
:
Role of
ERK/MAPK in
endothelin receptor signaling in human aortic smooth muscle cells
Sandhu et al., Toxicol Appl Pharmacol 2010
:
The present study was designed to examine if lipid-soluble ( dimethyl sulfoxide-soluble ) cigarette smoke particles ( DSP ) induces upregulation of contractile endothelin type B ( ET ( B ) ) receptors in rat cerebral arteries and if activation of mitogen activated protein kinase (
MAPK ) and nuclear factor-kappaB ( NF-?B )
mediate the upregulation of contractile
endothelin receptors in the cerebral arteries
Zhang et al., TheScientificWorldJournal 2010
(Cardiovascular Diseases...) :
Up-regulation of
endothelin receptors
induced by cigarette smoke -- involvement of
MAPK in vascular and airway hyper-reactivity
Rajapurohitam et al., Mol Cell Biochem 2012
(Hypertrophy) :
In addition, NF-?B inhibition significantly attenuated angiotensin II and
endothelin-1 induced p38
MAPK activation whereas inhibition of p38 MAPK blocked both angiotensin II- and endothelin-1 induced increases in leptin secretion
Peng et al., Pflugers Arch 2012
:
N-Acetyl-seryl-aspartyl-lysyl-proline ( Ac-SDKP ) inhibits
endothelin-1 (ET-1) induced activation of p44/42
mitogen activated protein kinase ( p44/42 MAPK ) and collagen production in cultured rat cardiac fibroblasts ( RCFs )
Lazou et al., Circ Res 1994
:
In isolated myocytes,
endothelin 1 ( 100 nmol/L for 5 minutes ) also
stimulated MAPK , but stimulation by norepinephrine or isoproterenol was difficult to detect ... In isolated myocytes,
endothelin 1 ( 100 nmol/L for 5 minutes ) also
stimulated MAPK , but stimulation by norepinephrine or isoproterenol was difficult to detect
Sugimoto et al., Biochem Biophys Res Commun 1993
:
Atrial natriuretic peptide inhibits
endothelin-1 induced activation of
mitogen activated protein kinase in cultured rat mesangial cells ... In cultured rat glomerular mesangial cells,
endothelin-1 (ET-1) activated both pp 44 and pp 42
mitogen activated protein ( MAP ) kinases ... In cultured rat glomerular mesangial cells,
endothelin-1 (ET-1)
activated both pp 44 and pp 42
mitogen activated protein ( MAP ) kinases
Sugimoto et al., J Diabetes Complications 1995
:
Cyclic nucleotides attenuate
endothelin-1 induced activation of
mitogen activated protein kinase in cultured rat mesangial cells
Schramek et al., J Cardiovasc Pharmacol 1995
:
To evaluate a possible mechanism for the chronic regulation of MAPK/ERK kinase-1 (MEK-1) and p42 mitogen activated protein kinase ( MAPK ) we studied the long-term
effects of the G-protein coupled receptor agonist
endothelin-1 (ET-1) and the protein tyrosine kinase coupled receptor agonist platelet derived growth factor BB ( PDGF BB ) on MEK-1 and p42
MAPK in glomerular mesangial cells ( GMCs )
Jones et al., Life Sci 1996
:
Effects of
endothelin on
mitogen activated protein kinase activity and protein synthesis in isolated adult feline cardiac myocytes
Guo et al., Hypertens Res 1996
:
Inhibitory effect of BQ-123 on
endothelin-1 stimulated
mitogen activated protein kinase and cell growth of rat vascular smooth muscle cells
Scott et al., Biochem J 1996
:
In bovine airway smooth-muscle cells platelet derived growth factor ( PDGF ) and
endothelin ( Et-1 )
stimulate sustained and comparable activation of
mitogen activated protein kinase ( MAP kinase ) but display very different mitogenic efficacies, with PDGF inducing 50 times more DNA synthesis than Et-1
Buist et al., Biochem Biophys Res Commun 1998
(Neuroectodermal Tumors, Primitive, Peripheral) :
Lysophosphatidic acid (LPA) and
endothelin-1 (ET-1) , two ligands for G-protein coupled receptors ( GPCRs ),
induce activation of mitogen activated protein kinase (
MAPK )
Dulin et al., Mol Cell Biol 1999
:
A role of RGS3 in postreceptor signaling was demonstrated by decreased calcium responses and
mitogen activated protein ( MAP ) kinase activity
induced by
endothelin-1 in HMC stably overexpressing RGS3
Kimura et al., Endocrinology 1999
:
The
regulation of
mitogen activated protein ( MAP ) kinase by
endothelin-1 (ET-1) in cultured rat puerperal uterine myometrial cells was investigated