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IRF6 — SOCS3

Text-mined interactions from Literome

Crespo et al., Eur J Immunol 2002 (MAP Kinase Signaling System) : These observations are mechanistically consistent with the known induction of suppressors of cytokine signaling (SOCS)-1 and SOCS-3 proteins by LPS ... The induction of SOCS-1 and SOCS-3 by LPS or IFN-beta ( an autocrine/paracrine mediator of LPS induced SOCS-1 mRNA synthesis ) occurs by way of multiple protein kinase pathways that include protein tyrosine kinases, protein kinase C, and mitogen activated protein kinases
Niemand et al., J Immunol 2003 (MAP Kinase Signaling System) : Although LPS induces the feedback inhibitor suppressor of cytokine signaling 3 ( SOCS3 ) in macrophages, inhibition of IL-6 signal transduction by LPS occurs rapidly and does not depend on gene transcription
Bode et al., J Immunol 2003 : Recently, it has been demonstrated that TNF-alpha and LPS induce the expression of suppressor of cytokine signaling 3 ( SOCS3 ) and inhibit IL-6 induced STAT3 activation in macrophages
Nishiki et al., Am J Physiol Cell Physiol 2004 (MAP Kinase Signaling System) : G-CSF mediated inhibition of LPS induced TNF-alpha production as well as G-CSF induced STAT3 phosphorylation and suppressor of cytokine signaling 3 mRNA expression were prevented by pretreatment of monocytes with AG-490, an inhibitor of Janus kinase 2
Yang et al., J Hepatol 2005 (Disease Models, Animal...) : Using IL-6-deficient mice we analyzed the role of interleukin-6 for the hepatic SOCS3 expression in response to turpentine and LPS as models of aseptic and bacterial inflammation, respectively
Prêle et al., Immunology 2006 : Although overexpression of SOCS3 to supraphysiological levels transiently antagonized the regulatory properties of IL-10 by a post-transcriptional mechanism, these findings suggest that under pathological conditions SOCS3 does not control LPS-activation or the anti-inflammatory properties of IL-10 in primary human monocytes
Orr et al., Blood 2007 (Inflammation) : Suppressor of cytokine signaling 3 ( SOCS3 ) is expressed in response to cytokines, LPS , and other PAMPs, and competes with SHP-1/2 binding to ITIMs of cytokine receptors, thereby inhibiting signaling
Zanin-Zhorov et al., J Immunol 2007 : LPS also up-regulated the T cell expression of suppressor of cytokine signaling 3 , which led to inhibition of T cell chemotaxis toward the chemokine stromal cell derived factor 1alpha ( CXCL12 )
Qin et al., J Immunol 2007 (MAP Kinase Signaling System) : An analysis of the SOCS-3 promoter indicates that AP-1 and IFN-gamma activation sequence ( GAS ) elements are involved in LPS induced SOCS-3 transcription ... LPS induced SOCS-3 expression was diminished in IL-10-deficient macrophages at later time points, indicating the involvement of endogenous IL-10 in this response ... Blocking STAT-3 expression and activation using STAT-3 small interfering RNA reduced LPS induced SOCS-3 gene expression ... LPS activated the MAPK-ERK1/2, JNK, and p38 pathways that, in addition to STAT-3, were also involved in LPS induced SOCS-3 expression ... These results indicate that LPS induced MAPK activation, the production of endogenous IL-10, and STAT-3 activation play critical roles in SOCS-3 expression, which provides for feedback attenuation of cytokine induced immune and inflammatory responses in macrophages and microglia
Dierssen et al., J Biol Chem 2008 (Acute-Phase Reaction...) : LPS and PH induced SOCS3 and APG in all animal strains and delayed cell cycle progression
Brown et al., J Neuroimmunol 2009 (Body Weight...) : LPS ( 25 microg/mL ; 3 h ) had no effect on rstn mRNA, but significantly stimulated fiaf and socs-3 expression ... Although various toll-like receptor 4 (TLR4) antagonists ( parthenolide, PD098059, and SB202190 ) did not prevent the LPS induced increases in fiaf and socs-3 , they did partially attenuate its stimulatory effects
Hirose et al., Biochem Biophys Res Commun 2009 : Among multiple LPS induced genes, the LPS induced expression of Socs-3 was significantly reduced by the treatment of RAW264.7 cells with an Atf-2 siRNA ... Transcription from the Socs-3 promoter was synergistically stimulated by ATF-2 and LPS , whereas it was suppressed by Atf-2 siRNA ... Treatment of RAW264.7 cells with trichostatin A, an inhibitor of HDAC, suppressed the LPS induced Socs-3 expression, suggesting that HDAC1 positively regulates the LPS induced transcription of Socs-3
Dagvadorj et al., Immunology 2010 : The LPS induced SOCS-3 expression was markedly augmented in macrophages from wild-type mice whereas such augmentation was not seen in the cells from TNF-a-deficient mice ... The addition of exogenous TNF-a augmented the LPS induced SOCS-3 expression in macrophages from TNF-a-deficient mice ... Moreover, MG 132, a 26S proteasome inhibitor, sustained the LPS induced SOCS-3 expression in those cells
Deopurkar et al., Diabetes Care 2010 (Inflammation) : Indexes of inflammation including nuclear factor-kappaB (NF-kappaB) binding, and the expression of SOCS3 , tumor necrosis factor-alpha (TNF-alpha), and interleukin (IL)-1beta in MNCs, increased significantly after glucose and cream intake, but TLR-4 expression and plasma LPS concentrations increased only after cream intake
de Lartigue et al., Am J Physiol Endocrinol Metab 2011 (Body Weight...) : In cultured VAN, LPS increased SOCS-3 expression and inhibited leptin induced pSTAT3 in vivo
Kerr et al., Neuroscience 2012 : URB597 attenuated the LPS induced increase in interleukin (IL)-1ß expression while concurrently augmenting the LPS induced increase in suppressor of cytokine signalling (SOCS)-3 expression
Minogue et al., Journal of neuroinflammation 2012 (MAP Kinase Signaling System) : Co-treatment of glia with LPS and recombinant IL-6 protein attenuated the LPS induced release of both TNF a and IL-1 ß while potentiating the effect of LPS on suppressor of cytokine signaling (SOCS)3 expression and IL-10 release