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IRF6 — PTX4
Text-mined interactions from Literome
Fan et al., Frontiers in bioscience : a journal and virtual library 2006
(Gram-Negative Bacterial Infections...) :
The induction of these cytokines was significantly ( p < 0.05 ) suppressed by PTx. Glucan treatment alone had no effect on cytokine production but suppressed ( P < 0.05 )
LPS and SA
induced cytokines.
PTx further augmented ( p > 0.05 ) the inhibitory effect of glucan on the LPS and SA induced cytokine expression
Parhar et al., Mediators Inflamm 1993
:
In the present study the
effects of
PTX on
lipopolysaccharide (LPS) and cytokine induced T-cell and macrophage ( PhiM ) activation, and on natural killer ( NK ) cell and lymphokine activated killer ( LAK ) cell mediated cytotoxicity were examined
Schratzberger et al., Immunopharmacology 1999
:
In the present study, we investigated the
effects of the anti-inflammatory drug
pentoxifylline ( PTX ) on activation of endothelial cells for enhanced adhesion and transmigration of neutrophils by
lipopolysaccharide (LPS) , tumor necrosis factor-alpha (TNF), interleukin-1 (IL-1) and granulocyte colony stimulating factor ( G-CSF ) ... Upon
stimulation with TNF or
LPS , HUVEC produced IL-8 and
PTX affected this process in opposing fashions, with inhibition of the effects of TNF and augmentation of those of LPS