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IRF6 — LANCL1

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Roy et al., Surgery 1999 : We harvested adherent peritoneal macrophages harvested from wild-type ( WT ), heterozygous c-fos knockout ( Hetero KO ), or homozygous c-fos knockout ( Homo KO ) mice and investigated lipopolysaccharide (LPS) induced IL-12 p70 protein synthesis ( by enzyme linked immunosorbent assay ), IL-12 p35 and IL-12 p40 messenger RNA accumulation ( mRNA ) ( by reverse transcriptase-polymerase chain reaction ), and the transcription rate ( by nuclear runoff )
Zhang et al., Cell Immunol 2000 : Furthermore, Proteasome Inhibitor I abolished the LPS induced mRNA expression of IL-12 p35 and p40 , and SB203580 reduced these mRNA levels, whereas the blockade of PKC, PKA, and ERK had little effect
Perera et al., J Immunol 2001 : Therefore, the relative contribution of these proteins in the induction of cyclooxygenase 2 (COX-2), IL-12 p35, IL-12 p40 , TNF-alpha, IFN-inducible protein (IP)-10, and IFN consensus sequence binding protein ( ICSBP ) genes in response to LPS or the LPS-mimetic, Taxol, was examined using macrophages derived from mice deficient for these membrane associated proteins
Haskó et al., Immunology 2001 : Sulphasalazine inhibited the LPS/IFN-gamma induced production of both interleukin-12 (IL-12) p40 and p70
Feng et al., Cell Res 2002 (Inflammation) : cAMP elevators inhibit LPS induced IL-12 p40 expression by interfering with phosphorylation of p38 MAPK in murine peritoneal macrophages
Petro et al., Int Immunopharmacol 2003 : Expression of p35 and p40 in response to lipopolysaccharide (LPS) and interferon (IFN)-gamma requires activation of nuclear factor-kappa-B (NF-kappaB) and interferon regulatory factor ( IRF ) transcription factors ... Expression of p35 and p40 in response to lipopolysaccharide (LPS) and interferon (IFN)-gamma requires activation of nuclear factor-kappa-B (NF-kappaB) and interferon regulatory factor ( IRF ) transcription factors ... In contrast, STE had no effect on LPS induced p35 and p40 promoter activity and diminished IFN-gamma/LPS induced p35 promoter activity
Goodridge et al., Immunology 2003 (MAP Kinase Signaling System) : Such Erk MAPkinase activation is downstream of calcium influx and targets LPS induced IL-12 p40 transcription by suppressing the synthesis of the transcription factor, interferon regulatory factor-1 (IRF-1)
Utsugi et al., J Immunol 2003 (MAP Kinase Signaling System) : Inhibition of p38 MAP kinase activation using SB203580 dose dependently repressed LPS induced IL-12 p40 production, as described ... Finally, the increase in the ratio of GSH/GSSG induced by glutathione reduced form ethyl ester ( GSH-OEt ) dose dependently enhanced LPS induced IL-12 p40 production in PMA treated THP-1 cells
Xiong et al., J Biol Chem 2004 : As a consequence, the NO donor S-nitroso-N-acetylpenicillamine (SNAP) inhibits lipopolysaccharide (LPS) induced IL-12 p40 mRNA expression, protein production, and promoter activity in murine macrophages, dendritic cells, and the murine macrophage cell line RAW 264.7
Hoentjen et al., Blood 2005 : Adenoviral gene delivery of a constitutively active STAT3 but not control green fluorescence protein ( GFP ) virus blocked LPS induced IL-12p40 gene expression and cRel recruitment to the IL-12p40 promoter
Xiong et al., J Biol Chem 2005 : Furthermore, IRF-8 induced IL-12 p40 synthesis in RAW264.7 cells was enhanced by dominant negative Cbl, and peritoneal macrophages from Cbl-/- mice showed increased IL-12 p40 protein production
An et al., Inflammation 2004 : In this study, using mouse peritoneal macrophages, we have examined whether XF affects nitric oxide ( NO ), tumor necrosis factor (TNF)-alpha, and interleukin (IL)-12p40 production induced by interferon (IFN)-gamma and lipopolysaccharide (LPS)
Ali et al., Circ Res 2005 (Inflammation) : Importantly, reconstitution of apoE expression in the liver of apoE-deficient mice normalized the LPS induced plasma protein levels of IL-12p40
Pathak et al., J Biol Chem 2005 : Man-LAM inhibits LPS induced IL-12 p40 expression in an IL-10 independent manner
Fronhofer et al., J Leukoc Biol 2006 : Similarly, activation of PKC with phorbol 12-myristate 13-acetate ( PMA ) depressed LPS stimulated IL-12p40 secretion, and depletion of PKC augmented LPS stimulated IL-12p40 secretion
Wang et al., J Clin Immunol 2007 : The effects of atRA on LPS induced mRNA expression of IL-10, IL-12p40 , TNF-alpha, IL-18, and TGF-beta in the THP-1 monocyte/macrophage cell line and in cord blood mononuclear cells were measured by competitive RT-PCR
Nakano et al., Blood 2007 (Bacterial Infections...) : The transcription levels of p35 and p40 were increased by stimulation of BMMCs with IFN-gamma/lipopolysaccharide (LPS)
Ripoll et al., J Immunol 2007 : Gpnmb overexpression in RAW264.7 cells caused a 2-fold reduction in the production of the cytokines IL-6 and IL-12p40 and the inflammatory mediator NO in response to LPS
Yamauchi et al., Int Immunol 2007 (Genetic Predisposition to Disease...) : Furthermore, overexpression of Ifi202 enhanced LPS induced IL-12p40 and IkappaB-zeta mRNA induction while Ifi202 AS RNA suppressed these in RAW 264.7 cells
Goyarts et al., Exp Dermatol 2008 : Furthermore, forskolin also inhibited the LPS induced levels of TNF-alpha, IL-12 p40 , IL-23 p19 and IL-6, supporting the hypothesis that the effects of NE are mediated by cAMP
Aldhous et al., Inflamm Bowel Dis 2008 (Colitis, Ulcerative...) : Stimulation by LPS and PHA ( 5 microg/mL ) increased IL12/IL23p40 production from CD and UC versus HC ( P < 0.05 ) ; PHA ( 0.5 microg/mL ) increased IL1beta in UC and decreased TGFbeta from CD and UC ( P < 0.01 )
Qi et al., Sci China C Life Sci 2000 : Promoting effect of IFN-gamma on the expression of LPS induced IL-12 p40 and p35 mRNA in murine suppressor macrophages ... It was found that IFN-gamma strongly enhanced the LPS induced IL-12 p40 and p35 mRNA expression ... Taken together, the data suggest : ( i ) IFN-gamma/LPS could strongly induce the expression of IL-12 p40 and p35 mRNA ; both the expression levels were equal ; this phenomenon coincided with the high-level secretion of IL-12 p70 induced by IFN-gamma/LPS ; ( ii ) NF-kappaB signal pathway is essential for IFN-gamma/LPS to induce IL-12 mRNA expression ; ( iii ) by blocking the degradation of IkappaB, the PSI suppresses the IL-12 p40/p35 mRNA expression induced by LPS and IFN-gamma/LPS ; ( iv ) NF-kappaB signal may not be involved in the mechanism by which IFN-gamma enhanced the expression of the LPS induced IL-12 p40/p35 mRNA
Joo et al., PloS one 2009 (Colitis...) : Moreover, LPS induced IL-12p40 gene expression was dose-dependently inhibited in TLE treated splenocytes
Shikama et al., Innate Immun 2011 (Shock, Septic) : Muramyldipeptide also : ( i ) increased pro-IL-1ß in tissues, but did not increase IL-1ß in serum ( since caspase-1 was not activated by MDP ) ; ( ii ) downregulated the expression of suppressor of cytokine signaling 1 ( SOCS1 ; a negative-feedback regulator of LPS induced signaling ) ; and ( iii ) augmented the LPS induced production of TNF-a, IL-12 p40 , and interferon ( IFN ) -?
Boucher et al., Viral Immunol 2010 (HIV Infections...) : These data clearly show that although LPS induces IL-12p40 expression in primary monocytes and THP-1 cells, the signaling pathways involved and the effect of HIV infection differ and can have disparate effects in these two cell types
Utsugi et al., Cytokine 2010 : Knockdown of JNK1 and JNK2 by small interference RNA ( siRNA ) reduced and enhanced LPS induced IL-12 p40 production in THP-1 macrophage cells, respectively
Ko et al., Immune network 2010 : We first demonstrate its effects on LPS stimulated pro-inflammatory cytokine production including interleukin (IL)-6 and IL-12p40
Lysakova-Devine et al., J Immunol 2010 : VIPER was TLR4 specific, being inert toward other TLR pathways, and was active in murine and human cells and in vivo, where it inhibited LPS induced IL-12p40 secretion
Ueda et al., Int Immunol 2010 : Colonic DCs ( LDC ) showed LPS induced production of IL-12p40
Kasai et al., J Med Invest 2011 (Bone Diseases, Metabolic) : In in vitro cultures, raloxifene at a concentration ( 10 ( -9 ) M ) inhibited LPS stimulated production of IL-1ß, IL-6 and IL-12p40 and PHA stimulated production of IFN-?
Song et al., BMC complementary and alternative medicine 2011 (Colitis...) : LPS induced IL-12p40 , IL-23p19, IL-6 and IL-1ß mRNA expressions were inhibited by BTE
Mora et al., Cell cycle (Georgetown, Tex.) 2012 : For this purpose, we investigated the effect of bindarit on the LPS induced production of inflammatory cytokines ( MCP-1 and MCPs, IL-12ß/p40 , IL-6 and IL-8/KC ) in both a mouse leukaemic monocyte-macrophage cell line and bone marrow derived macrophages ( BMDM )
Kiem et al., Chem Pharm Bull (Tokyo) 2012 (Inflammation) : Among of them, compounds 1-3 were potent inhibitors of LPS stimulated interleukin-6 (IL-6) and IL-12 p40 , with IC ( 50 ) ranging from 4.1±0.2 to 9.1±0.3?µM
Joo et al., Gut and liver 2012 : EGCG inhibited accumulation of LPS induced IL-12p40 , IL-6, MCP-1, ICAM-1, and VCAM-1 mRNA in BMMs. EGCG blocked LPS induced I?Ba degradation and RelA nuclear translocation ... U0126 ( an inhibitor of MEK-1/2 ) suppressed the LPS induced IL-12p40 , IL-6, MCP-1, ICAM-1, and VCAM-1 mRNA accumulation in BMMs
Hildebrand et al., Cell communication and signaling : CCS 2012 : Here we show that the activation of heterotrimeric G proteins through PMT suppresses LPS stimulated IL-12p40 production and eventually impairs the T cell activating ability of LPS treated monocytes
Thao et al., Chem Pharm Bull (Tokyo) 2012 : Among them, compounds 2, 3, and 11 were potent inhibitors of LPS stimulated interleukin-12 (IL-12) p40 with half-maximal inhibitory concentration ( IC ( 50 ) ) values ranging from 4.35±0.12 to 18.04±0.21?µM. Compounds 2, 3, and 11 showed moderate inhibitory activity on IL-6 production with IC ( 50 ) values ranging from 17.72±0.31 to 59.77±2.34?µM
Fraternale et al., PloS one 2013 : Under these experimental conditions, GSH-C4 and I-152 enhanced and suppressed respectively the mRNA expression levels of IL-12 p40 induced by LPS/IFN-? as assessed by Real-Time PCR
Kang et al., Life Sci 2013 (Colitis...) : GG-52 significantly inhibited LPS induced IL-12p40 and TNF-a gene expression, I?Ba degradation, and NF-?B DNA binding activity in BMDCs
Hayes et al., Blood 1995 : Time course experiments demonstrated independent regulation of p40 and p35 by IFN-gamma and LPS ... Finally, both p40 and p35 were directly induced by LPS in the presence of cycloheximide
Rook et al., J Immunol 1995 (Sezary Syndrome...) : Despite normal numbers of peripheral blood monocytes and normal TNF-alpha production, mean Staphyloccus aureus and LPS induced IL-12 p40 and p70 production by SzS PBMC was significantly decreased compared with PBMC from normal controls
D'Andrea et al., J Exp Med 1993 : NKSF/IL-12 p40 chain mRNA accumulation is strongly induced by S. aureus or LPS and downregulated by IL-10, whereas the p35 mRNA is constitutively expressed and only minimally regulated by S. aureus, LPS, or IL-10
Salkowski et al., Infect Immun 1997 : LPS was a more potent inducer of IL-12 p35, IL-12 p40 , and IFN-gamma mRNA, as well as of IL-12 protein, than MPL
Du et al., J Leukoc Biol 1998 : Mechanism of inhibition of LPS induced IL-12p40 production by IL-10 and TGF-beta in ANA-1 cells
Isler et al., Am J Respir Cell Mol Biol 1999 : Both p35 and p40 mRNA levels were induced by lipopolysaccharide (LPS) and were further increased by interferon-gamma (IFN-gamma)