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EPHB2 — IRF6

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Monick et al., J Immunol 1999 : LPS induced ERK kinase activation was inhibited by tricyclodecan-9-yl xanthogenate ( D609 ), a relatively specific inhibitor of PC-PLC
Arbabi et al., J Surg Res 1999 : In addition, HTS and LPS induce activation of ERK which is required for PGI2 production
Tominaga et al., Biochim Biophys Acta 1999 : Although a monosaccharide lipid A analog, GLA-58, was able to stimulate macrophages to activate ERK proteins without cytokine production, pretreatment of macrophages with this compound suppressed both LPS stimulated activation of ERK and cytokine production
Vittimberga et al., J Surg Res 1999 : LPS stimulated activation of ERK and SAPK/JNK was inhibited by NaSal pretreatment
van der Bruggen et al., Infect Immun 1999 : Ro 09-2210 completely prevented LPS induced ERK1 and ERK2 activation
Nolan et al., Surgery 1999 : LPS inhibited PMN apoptosis and activated p38 and ERK in a dose- and time dependent fashion
Yang et al., J Biol Chem 2000 : When MD-2, a protein associated with the extracellular domain of TLR4, was expressed in these cells, there was a marked increase in Elk-1 activity as well as ERK , JNK, and p38 MAP kinase phosphorylation in response to LPS
Kim et al., Brain Res 2000 (Glioma) : Furthermore, LPS plus CHX enhanced phosphorylation of ERK , p38, and CREB in a synergistic manner
Monick et al., J Immunol 2000 : Kinase activity assays showed that LPS activates PKC zeta, mitogen activated protein/ERK kinase ( MEK, the upstream activator of ERK ), and ERK ... We found that a peptide specific for PKC zeta partially blocked activation of both MEK and ERK by LPS
Heagy et al., J Trauma 2000 (Inflammation...) : Pretreatment of murine macrophages with LPS induces LPS-tolerance, with inhibition of LPS stimulated activation of kinases ( ERK1/2 and p38 ) and diminished release of tumor necrosis factor (TNF)
Dumitru et al., Cell 2000 (MAP Kinase Signaling System...) : LPS stimulation of peritoneal macrophages from these mice did not activate MEK1, ERK1, and ERK2 but did activate JNK, p38 MAPK, and NF-kappaB
Bonner et al., Infect Immun 2001 : We found that LPS activated ERK 1 and 2 in cells of both adults and newborns and that activation was plasma dependent ( maximal at > or =5 % ) through LPS binding protein ... Although fibronectin in plasma is required for LPS mediated priming of neutrophils of adults assessed by fMLP triggered oxidative burst, it was not required for LPS mediated activation of ERK 1 and 2 ... While Western blotting showed that 100 microM PD 98059 completely inhibited LPS mediated ERK activation, oxidative response to fMLP by a chemiluminescence assay revealed that the same concentration inhibited the LPS primed oxidative burst by only 40 % ... We conclude that in neutrophils, LPS mediated activation of ERK 1 and 2 requires plasma and that this activation is not dependent on fibronectin
Klein et al., Cell Signal 2001 (MAP Kinase Signaling System) : LPS , fMLP, and LTB ( 4 ) stimulated similar levels of ERK and Akt activation
Yi et al., Int Immunol 2001 : Although CpG DNA at the higher concentration slightly enhanced LPS mediated phosphorylation of ERK , it did not alter the LPS mediated activation of c-Jun N-terminal kinase and p38
Watters et al., J Biol Chem 2002 : Although LPS potently stimulates ERK activation in RAW 264.7 macrophages, it does not activate ERK-1/-2 in BV-2 microglia ... Moreover, antagonism of the MEK/ERK pathway potentiates LPS stimulated nitric oxide production, suggesting that LPS stimulated ERK activation can exert inhibitory effects in macrophage-like cells
Zhang et al., Chin J Traumatol 2001 (Endotoxemia...) : In mKC, LPS treatment resulted in transient and rapid increase of kinase activity of ERK1/2 that phosphorylated their specific substrate ELK-1, with maximal value at 30 minutes and a return near to baseline within 2 hours, and LPS induced ERK1/2 activity from LPS concentration of 10 pg/ml to the top activity at 100 ng/ml
Barbosa de Oliveira et al., Braz J Med Biol Res 2002 : Finally, there was a cell density dependent LPS effect on protein tyrosine phosphatase (PTP) and ERK1/ERK2 mitogen activated protein ( MAP ) kinase activities
Zirngibl et al., Mol Cell Biol 2002 : Bone marrow derived Fps/Fes-null macrophages showed no defects in granulocyte-macrophage colony stimulating factor-, interleukin 6 (IL-6)-, or IL-3 induced activation of signal transducer and activator of transcription 3 ( Stat3 ) and Stat5A or LPS induced degradation of I kappa B or activation of p38, Jnk, Erk , or Akt
Takeda et al., Invest Ophthalmol Vis Sci 2002 (Uveitis) : The present study suggests that LPS stimulation activates ERK in Müller cells, whereas the total amount of ERK is unchanged ... Because the LPS induced p-ERK level was reduced by Dex treatment, its expression seems to be associated with ocular inflammatory stimulus
Shi et al., Am J Physiol Cell Physiol 2002 : Using a chloramphenicol acetyltransferase reporter gene linked to the Egr-1 promoter, we show that LPS increased Egr-1 promoter activity via an ERK1/2 dependent mechanism
Rao et al., J Toxicol Environ Health 2002 (MAP Kinase Signaling System) : In the three cell lines examined, all three families of MAPKs were activated upon stimulation with either lipopolysaccharide (LPS) or LPS plus interferon-gamma ; in contrast, only ERK1/2 was activated in primary rat alveolar macrophages upon stimulation with LPS
Li et al., Endocrinology 2002 : Nevertheless, LPS induced degradation of IkappaB and phosphorylation of ERK in osteoclasts as well as in osteoclast precursors
Woo et al., Mol Cells 2002 (MAP Kinase Signaling System) : Our results showed that LPS induced the activation of ERK and p38 MAP kinase in a Rac dependent manner, suggesting a mediatory role of Rac1 in LPS signaling to MAPKs stimulation
Xagorari et al., Br J Pharmacol 2002 : Pretreatment of RAW 264.7 with luteolin inhibited the LPS induced ERK1/2 and p38, but not JNK1/2, phosphorylation, and blocked the LPS induced TNF-alpha release
Jiang et al., Shock 2002 (Inflammation...) : These data indicate that LPS stimulation, although not inducing any change in protein expression, results in rapid activation of ERK1/2 , p54JNK, and p38 kinases in KCs, and that they may have different importance in the regulation of pro- and anti-inflammatory responses by LPS stimulated KCs
Jiang et al., Zhonghua Yi Xue Za Zhi 2002 (MAP Kinase Signaling System) : ERK1 , JNK1, and p38 MAPKs were transiently activated by LPS
Heagy et al., Shock 2003 (MAP Kinase Signaling System) : LPS induced endotoxin-tolerance with a significant inhibition of LPS stimulated TNF secretion and less p44/p42 ERK kinase activation ... LPS stimulated p44/p42 ERK kinase activation and TNF release were diminished whether or not anti-CD14 antibody was present during LPS pretreatment ... LPS stimulated TNF secretion and p44/p42 ERK kinase activation require the presence of serum and are inhibited by anti-CD14 antibody
Lai et al., J Immunol 2003 : Thus, LPS induction of MMP-1 production by monocytes is regulated by both ERK1/2 and p38, whereas MMP-9 stimulation occurred mainly through the ERK1/2 pathway
Kikuchi et al., J Dent Res 2003 : These findings indicate that Cot/Tpl2 is essential for LPS induced ERK activation and RANKL induction in osteoblasts
Eliopoulos et al., EMBO J 2003 : Macrophages from Tpl2 knockout ( Tpl2 ( -/- ) ) mice exhibit a defect in ERK activation by lipopolysaccharide (LPS)
Soldatos et al., Insect Biochem Mol Biol 2003 : The response of hemocytes to these stimuli denoted that hemocyte ERK is evidently stimulated by at least an LPS receptor and via an integrin mediated process
Xie et al., J Immunol 2003 : Furthermore, LPS up-regulated the secretion of IL-1beta, IL-6, IL-8, IL-10, and TNF-alpha ; reduced Ag presentation capacity ; and inhibited phosphorylation of ERK , but activated p38, leading to a reduced NF-kappaB activity in treated cells
Kojima et al., Am J Physiol Gastrointest Liver Physiol 2004 (MAP Kinase Signaling System) : Whereas LPS stimulated both the p38 and ERK1/2 but not the stress activated protein kinase/c-Jun NH ( 2 ) -terminal kinase, signaling pathways in the YAMC cells, all three were stimulated in RAW macrophage cells ( in which no LPS induced HSP25 expression was observed )
Huang et al., Nat Immunol 2004 : Furthermore, MEKK3 is crucial for IL-1- and LPS induced activation of NF-kappaB and JNK-p38 but not ERK , indicating that MAPKs are differentially activated during IL-1R-TLR4 signaling
Nishiki et al., Am J Physiol Cell Physiol 2004 (MAP Kinase Signaling System) : G-CSF did not affect LPS induced activation of ERK , p38, JNK, and NF-kappa B, indicating that G-CSF affects the pathway downstream or independently of these signaling molecules
Kesavan et al., J Cell Physiol 2004 : Bacterial lipopolysaccharide (LPS) and TNFalpha neither activate ERK5 nor require MEKK2 for JNK activation, demonstrating specificity of MEKK2 in FGF-2 receptor signaling and control of cytokine gene expression
Serikov et al., J Endotoxin Res 2004 : The first aim was to determine whether LPS induces ERK1/2 activation and changes in epithelial permeability in epithelial cells alone or only in the presence of immune cells
Balaraman et al., Biochem Biophys Res Commun 2004 : The use of inhibitors selective for ERK ( PD98059 ) and p38 ( SB203580 ) mitogen activated protein ( MAP ) kinase pathway showed that preincubation of cells with either SB203580 or PD98059 did not affect the binding activity of IRF-E, suggesting that both p38 and ERK MAP kinase activation are not necessary for IRF-E activation
Weiss et al., Antimicrob Agents Chemother 2004 : Activation of ERK1/2 and the 46-kDa p-JNK protein was enhanced by LPS and LPS-PMA and was significantly inhibited by MXF ( 54 and 42 %, respectively, with MXF at 10 microg/ml )
Cuschieri et al., J Surg Res 2004 : LPS stimulation led to the mobilization of TLR4 to lipid rafts followed by phosphorylation and activation of IRAK, ERK 1/2, p38, and JNK/SAPK
Lee et al., Respir Res 2004 (MAP Kinase Signaling System...) : SP600125 or PD98059 inhibited LPS induced phosphorylation of JNK and ERK , total protein and LDH activity in BAL fluid, and neutrophil influx into the lungs
Choi et al., Arch Pharm Res 2004 : Tanshinones exerted inhibitory activities on the LPS induced nitric oxide production only when applied concurrently with LPS, and tanshinone-IIA and cryptotanshinone were found to inhibit LPS induced NF-kappaB mobilization and extracellular regulated kinase (ERK) activation, respectively
Shinohara et al., J Exp Med 2005 : The stimulation with LPS of macrophages from mice lacking Dok-1 or Dok-2 induced elevated Erk activation, but not the other MAP kinases or NF-kappaB, resulting in hyperproduction of TNF-alpha and nitric oxide ... Forced expression of either adaptor, but not a mutant having a Tyr/Phe substitution, in macrophages inhibited LPS induced Erk activation and TNF-alpha production
An et al., Blood 2005 (Inflammation) : Neither disrupting phosphatase activity nor using the PI-3K pathway inhibitor LY294002 or wortmannin could significantly block SHIP1 mediated inhibition of LPS induced ERK1/2 , p38, and JNK activation and TNF-alpha production, demonstrating that SHIP1 inhibits LPS induced activation of MAPKs and cytokine production primarily by a phosphatase activity- and PI-3K independent mechanism
Peng et al., Circulation 2005 (Cardiomyopathies) : NADH oxidase activation by LPS increased ERK1/2 and p38 phosphorylation, and inhibition of ERK1/2 and p38 phosphorylation blocked the effect of NADH oxidase on TNF-alpha expression
Kim et al., Immunopharmacol Immunotoxicol 2005 : In contrast, mercury alone had no effect on activation of extracellular signal regulated kinase ( ERK ) but inhibited LPS induced ERK activation ... Mercury modulates LPS induced p38 and ERK activation and downstream TNFalpha and IL-6 expression in mouse liver
Brun et al., Am J Physiol Gastrointest Liver Physiol 2005 (Inflammation...) : These LPS mediated effects in HSCs were receptor dependent, because LPS induced ERK1 phosphorylation, IL-6, and MCP-1 mRNA and protein level upregulation were significantly less pronounced in HSCs isolated from C3H/HeJ mice lacking Toll-like receptor 4
Yang et al., Am J Physiol Heart Circ Physiol 2005 (Vasculitis) : Expression of a dominant negative form of TLR4 in human SMC attenuated LPS induced ERK1/2 and MCP-1 release
Lee et al., Br J Pharmacol 2005 : AP-1 promoter activity and p38 MAPK activation but not PKC, ERK and JNK activation induced by LPS were attenuated by oregonin
Han et al., Bioorg Med Chem Lett 2005 : As expected, the coumarin compounds potently inhibit LPS induced TNFalpha production and ERK phosphorylation in THP-1 cells, with the most potent compound having an IC ( 50 ) of 90nM
Gutiérrez-Venegas et al., Life Sci 2006 : These findings demonstrate that LPS from A. actinomycetemcomintans increases rapidly p44 and p42 phosphorylation ( ERK 1 and ERK 2, respectively ) in human gingival fibroblasts
Saito et al., J Pharmacol Sci 2005 : Activation of extracellular regulated kinase (ERK) by LPS was markedly attenuated in both macrophages isolated from in vivo daunorubicin treated rats and those incubated in vitro with daunorubicin at 1 microM
David et al., J Immunol 2005 : In that pharmacological inhibitors of PI3K inhibited LPS induced activation of p21Ras, but not activation of ERK, we concluded that LPS induced activation of ERK occurs through a pathway that is not dependent on the activation of p21Ras
Thakur et al., Am J Physiol Gastrointest Liver Physiol 2006 : gAcrp suppressed LPS stimulated ERK1/2 and p38 phosphorylation as well as IkappaB degradation at 100-1,000 ng/ml in Kupffer cells from both pair- and ethanol fed rats ... However, only LPS stimulated ERK1/2 phosphorylation was sensitive to 10 ng/ml gAcrp ... Suppression of LPS stimulated ERK1/2 signaling by low concentrations of gAcrp was associated with normalization of TNF-alpha production by Kupffer cells after chronic ethanol exposure
Zhao et al., J Biol Chem 2006 : IFN-gamma enhanced lipopolysaccharide (LPS) induced ERK and JNK phosphorylation but had no effect on LPS induced NF-kappaB activation ... Interestingly, we found that IRF-8-/- macrophages were impaired in the activation of LPS induced ERK and JNK and the production of proinflammatory cytokines induced by LPS or IFN-gamma plus LPS
Suh et al., Arch Biochem Biophys 2006 : The findings herein show that the inhibition of LPS induced ERK1/2 activation may be a contributing factor to the main mechanisms by which OC inhibits RAW264.7
Thakur et al., J Leukoc Biol 2006 : Chronic ethanol feeding increases activation of NADPH oxidase by lipopolysaccharide in rat Kupffer cells : role of increased reactive oxygen in LPS stimulated ERK1/2 activation and TNF-alpha production ... However, only LPS stimulated ERK1/2 phosphorylation was inhibited by DPI, which also reduced LPS stimulated TNF-alpha production in Kupffer cells from pair- and ethanol fed rats
Shan et al., Am J Physiol Lung Cell Mol Physiol 2006 (Asthma...) : Collectively, these data support the novel concept that TLR4 activation in ASM elicits changes in ASM function that are regulated by opposing effects of MAPK signaling, wherein LPS induced ERK1/2 activation mediates NF-kappaB dependent proasthmatic-like changes in ASM function, whereas coactivation of p38 MAPK serves to homeostatically downregulate the proasthmatic effects of ERK1/2 activation
Nakamura et al., J Biol Chem 2006 (MAP Kinase Signaling System) : In Raw 264.7 cells treated with MNSFbeta small interfering RNA ( siRNA ) lipopolysaccharide (LPS) induced ERK1/2 activation was enhanced and LPS induced JNK and p38 activation was unaffected ... Finally, we found that transfection with MNSFbeta expression construct resulted in a significant inhibition of LPS induced ERK activation and TNFalpha production
Yang et al., Mol Immunol 2007 : Moreover, LPS activated NFkappaB p65, ERK1/2 and JNK1/2 and induced their translocation to the nucleus
Liu et al., J Neurosci Res 2006 : NO had no effect on LPS stimulated ERK1/2 and p38 MAPK activation, suggesting that the inhibitory action of NO occurs downstream of MAPK cascades
Prêle et al., Immunology 2006 : SOCS3 over-expression had no effect on TNF-alpha mRNA levels induced by LPS or LPS plus IL-10, or on IL-10 phosphorylation of STAT3, STAT1 and ERK1/2
Parameswaran et al., J Biol Chem 2006 : We find that lipopolysaccharide (LPS) induced ERK1/2 phosphorylation is significantly enhanced in arrestin-2 and GRK5 knockdown cells ... Taken together, these results suggest that p105 phosphorylation by GRK5 and binding of arrestin-2 negatively regulates LPS stimulated ERK activation
Rani et al., Immunobiology 2006 (Disease Models, Animal...) : LPS induced phosphorylation of ERK1/2 was also decreased in peritoneal macrophages isolated after haemorrhagic shock
Kogut et al., Mol Immunol 2007 : The role of Ras activation in LPS induced stimulation of ERK1/2 was corroborated when the specific Ras inhibitor, FTI-277, inhibited ERK1/2 activation
Bolon et al., J Cell Physiol 2007 : We propose that LPS reduces inter-endothelial electrical coupling via tyrosine-, ERK1/2- , PKA-, and PKC dependent signaling that targets Cx40
Thorley et al., J Immunol 2007 : Macrophage ( but not ATII cell ) responses to LPS required activation of ERK1/2 and p38 MAPK signaling cascades ; phosphorylated ERK1/2 was constitutively up-regulated in ATII cells
Sherry et al., J Immunol 2007 (Diabetes Mellitus, Type 2) : LPS dependent stimulation of PI3K activity, ERK1/2 activation, and p38 kinase activity was greater in PerMphi from db/db mice as compared with db/+ mice
Wu et al., Int Immunopharmacol 2007 : Ginsenosides inhibited the phosphorylation of c-Jun NH2-terminal kinase (JNK), c-Jun and extracellular signal regulated kinase ( ERK ), The findings herein show that the inhibition of LPS induced ERK1/2 and JNK activation may be a contributing factor to the main mechanisms by which ginsenosides inhibits RAW264.7
Toshchakov et al., J Immunol 2007 (MAP Kinase Signaling System) : TLR4- and TLR2-BBPs also strongly inhibited LPS induced activation of ERK
Sánchez-Tilló et al., J Biol Chem 2007 (MAP Kinase Signaling System) : Lipopolysaccharide (LPS) induces macrophage activation, stops proliferation, and delays ERK phosphorylation, thereby triggering an inflammatory response
Fan et al., Mol Immunol 2007 (Inflammation) : Over expression of wild type beta-arrestins 1 and 2 had no effect on LPS induced ERK1/2 activation and LPS induced IL-8 production suggesting that endogenous beta-arrestins 1 and 2 are sufficient to mediate maximum ERK 1/2 activity and IL-8 production
Park et al., Int Immunopharmacol 2007 (Inflammation) : Molecular mechanisms that govern attenuation of the levels of mRNAs and proteins of these cytokines and iNOS revealed that the PC extract inhibited LPS stimulated phosphorylation of ERK and activation of NF-kappaB
Li et al., Blood 2007 : Functional differences between TGF-M-DCs and TGF-GM-DCs included enhanced responses to LPS induced ERK , JNK, and P38 activation in TGF-M-DCs and their immune suppressive skewed cytokine release profiles
Hung et al., Pediatr Allergy Immunol 2007 : LPS induced pp38 and p-ERK expression of THP-1 monocytic cells was suppressed by ketotifen ... The suppressive effect on MDC and IP-10 may, at least in part, involve the down-regulation of LPS induced p38 and ERK-MAPK expression
Gutiérrez-Venegas et al., Int Immunopharmacol 2007 : Our results showed that LPS treatment induces activation of extracellular signal related kinase 1/2 ( ERK1/2 ), p38, and c-jun-NH ( 2 ) -terminal kinase ( JNK )
Robinson et al., Mol Cell Biol 2007 : LPS activation of ERK requires TPL-2 release from associated NF-kappaB1 p105, which blocks TPL-2 access to its substrate, the ERK kinase MEK ... TPL-2 ( S400A ) expression also failed to reconstitute LPS activation of ERK and induction of TNF in Map3k8 ( -/- ) macrophages, which lack endogenous TPL-2
Hall et al., J Biol Chem 2007 (Arthritis, Rheumatoid...) : We have developed a series of highly selective and potent Tpl2 inhibitors, and in the present study we have used these inhibitors to demonstrate that the catalytic activity of Tpl2 is required for the LPS induced activation of MEK and ERK in primary human monocytes
Ostrowska et al., Biochem Biophys Res Commun 2008 : Thus, activation of PARs but not stimulation with LPS leads to ERK1/2 and JNK mediated production of IL-8
Komura et al., Journal of thrombosis and haemostasis : JTH 2008 : Pretreatment with KT5720, a protein kinase A inhibitor, reversed the inhibitory effect of AT on the LPS induced phosphorylation of ERK1/2
Jung et al., Exp Mol Med 2007 (Inflammation) : The molecular mechanisms that underlie celastrol mediated attenuation were the inhibition of LPS induced phosphorylation of MAPK/ERK1/2 and the DNA binding activity of NF-kappaB in BV-2 cells
Wu et al., Toxicol Appl Pharmacol 2008 : Additional studies with murine macrophages expressing wild type and mutated TLR4 showed that TLR4 was implicated in LPS induced ERK and NFkappaB activation, and CD40 expression
Singru et al., Endocrinology 2008 : Intracerebroventricular administration of the MAPK inhibitor, PD98059, prevented LPS induced ERK1/2 phosphorylation, c-fos activation, and the increase of CRH gene expression in the PVN but had no effect on c-fos activation in brainstem A2-C1/C2 regions ... We conclude that LPS rapidly increases the phospho-ERK1/2 in CRH containing neurons in the PVN and that activation of MAPKs is necessary for LPS induced activation of the hypothalamic-pituitary-adrenal axis
Ou et al., Respirology 2008 : However, LPS stimulated expression of p38 and ERK1/2 in airway epithelium was not affected by roxithromycin
Pace et al., Immunology 2008 : The LPS increased the expression of TLR4 and induced both NF-kappaB and ERK1/2 activation
Qian et al., Parkinsonism Relat Disord 2007 : Further studies showed that 10 ( -14 ) M DPI significantly reduced LPS induced ERK phosphorylation
Hickey et al., J Leukoc Biol 2008 : CyaA enhanced LPS induced phosphorylation of p38 MAPK and ERK in DC, and inhibitors of p38 MAPK, MEK, or NF-kappaB suppressed IL-10 production in response to LPS and CyaA
Bolon et al., J Cell Physiol 2008 (Sepsis) : We conclude that LPS + H/R initiates tyrosine kinase- and ERK1/2-sensitive signaling that synergistically reduces inter-endothelial electrical coupling by dephosphorylating PKA-specific serine residues of Cx40
Qian et al., J Immunol 2008 (Inflammation) : In addition, LPS induced ERK phosphorylation and subsequent Ser345 phosphorylation on p47phox were significantly inhibited by TGF-beta1 pretreatment
Kim et al., J Microbiol Biotechnol 2008 (MAP Kinase Signaling System) : Moreover, PGA1 inhibited LPS induced ERK phosphorylation
Sundararaj et al., J Leukoc Biol 2008 : Simvastatin also inhibited LPS stimulated ERK but not p38 MAPK and JNK ... Finally, we showed that the inhibition of LPS stimulated ERK activation by simvastatin was reversed by GGPP
Byeon et al., J Ethnopharmacol 2008 (Disease Models, Animal...) : The blockade of inflammatory mediators by taheebo seemed to be the result of the interruption of extracellular signal related kinase ( ERK ) activation, according to immunoblotting analysis and the NO assay, where LPS strongly induced the phosphorylation ( a hallmark of activation ) of ERK , and U0126, a selective ERK inhibitor, was found to strongly inhibit PGE ( 2 ) production
Park et al., J Biol Chem 2008 : Treatment with gAcrp decreased LPS stimulated ERK1/2 phosphorylation and IkappaB degradation and suppressed the ability of LPS to increase the DNA binding activity of Egr-1 and p65
Pocivavsek et al., Glia 2009 (Inflammation) : LPS induced both ERK and JNK activation, whereas EP induced ERK activation, but drastically reduced JNK activation
Dhungana et al., Mol Cell Proteomics 2009 : Given previous reports of an essential role for proteasomal degradation of IkappaB kinase phosphorylated p105 in LPS activation of ERK mitogen activated protein kinase, we tested for a role of rafts in compartmentalization of these events
Tsai et al., Inflammation 2008 : Furthermore, ATRA suppressed the expression of LPS stimulated c-Raf, MKK1/2 and ERK expression of THP-1 cells
Miksa et al., Int J Mol Med 2008 (Inflammation) : LPS induced phosphorylation of ERK1/2 , p38 and JNK is more enhanced in RPM compared to TGPM
Zhang et al., Cell Signal 2009 (MAP Kinase Signaling System) : Lithium also promotes the activation of Tpl2 and ERK by the TLR4 ligand LPS
Finzi et al., J Immunol 2009 (Biliary Tract Neoplasms...) : LPS induced early phosphorylation of EGFR and ERK1/2 in both types of cells, which reached maximum levels within 30 min ( first phase )
Kim et al., J Pharmacol Sci 2009 : As a mechanism of action, MSA inhibited LPS induced activation of NF-kappaB, ERK , p38, and JNK, which played pivotal roles in toll-like receptor 4-mediated DC maturation
Lee et al., J Ethnopharmacol 2009 : Then, BV inhibited LPS induced expression of PKC-alpha and MEK/ERK , not p38 and JNK
Li et al., Int Arch Allergy Immunol 2009 : Inhibition of ERK , JNK or p38 MAPK had little discernible effect on LPS-inducible CRAMP gene expression
Lin et al., Chem Biol Interact 2009 : LPS- and LTA induced NOS/NO productions were significantly suppressed by the JNK inhibitor, SP600125, but not by the ERK inhibitor, PD98059, through a reduction in JNK protein phosphorylation
Wu et al., Br J Pharmacol 2009 : Effects of tripterine were investigated on endothelial barrier function, inducible nitric oxide synthase (iNOS) expression, nicotinamide adenine dinucleotide phasphate ( NADPH ) oxidase activity, 3-nitrotyrosine formation, protein phosphatase type 2A (PP2A) activity, activation of extracellular regulated kinase (ERK) , c-Jun terminal kinase (JNK) and Janus kinase ( Jak2 ), and degradation of IkappaB in microvascular endothelial cells exposed to pro-inflammatory stimulus [ lipopolysaccharide (LPS) + interferon gamma (IFNgamma) ] and on vascular permeability in air pouches of mice injected with LPS + IFNgamma ... LPS + IFNgamma stimulated phosphorylation of ERK , JNK and Jak2, and degradation of IkappaB, but only Jak2 phosphorylation was sensitive to tripterine ( 50-200 nM )
Nam et al., Can J Physiol Pharmacol 2009 : In addition, Chunghyuldan significantly decreased LPS induced phosphorylation of the ERK1/2 and p38 signaling proteins
Li et al., J Ethnopharmacol 2009 : LPS induced phosphorylation of ERK1/2 and p38 were inhibited by TMP
Yang et al., J Immunol 2009 : Increased LPS induced cytokine expression in the absence of ANXA1 was accompanied by significantly increased LPS induced activation of ERK and JNK MAPK and was abrogated by inhibition of either of these pathways
Lacour et al., J Immunotoxicol 2009 : Moreover, we found that p38MAPK, JNK, and ERK were activated by APAP or LPS alone or in association
Lai et al., J Agric Food Chem 2009 : We also found that rosmanol suppressed LPS induced phosphorylation of ERK1/2 , p38 mitogen activated protein kinase ( MAPK ) and phosphatidylinositol 3-kinase (PI3K)/Akt signaling
Seo et al., Bone 2010 (MAP Kinase Signaling System...) : LPS induced M-CSF expression is mediated by ERK
Kim et al., Biochem Biophys Res Commun 2010 : In the present study, we confirmed the inhibition of nuclear translocation of activated p-ERK1/2 and NF-kB p50 in response to growth stimuli or LPS in the senescent human diploid fibroblasts
Brandenburg et al., Inflamm Res 2010 (Inflammation) : SF inhibits LPS stimulated ERK1/2 and JNK phosphorylation and thereby inhibits the LPS induced activation of NF-kappaB- and activator protein-1 (AP-1)
Watford et al., J Immunol 2010 (Pneumonia) : The protein kinase encoded by the Tpl2 proto-oncogene regulates ERK activation and cytokine gene expression in macrophages in response to LPS and TNF-alpha
Wang et al., Lab Invest 2010 (Disease Models, Animal...) : LPS/GalN mediated phosphorylation of JNK1/2 and ERK1/2 was differentially regulated in wild-type and PXR-null mice
González-Navajas et al., J Clin Invest 2010 (Colitis...) : Mechanistically, LPS stimulation of TLR4 bearing CD4+ T cells inhibited ERK1/2 activation upon subsequent TCR stimulation via the induction of MAPK phosphatase 3 (MKP-3)
Xuan et al., Cell Physiol Biochem 2010 : Moreover, LPS induced phosphorylation of prosurvival kinases Akt and ERK1/2 was abrogated by thymoquinone
Yoon et al., Food Chem Toxicol 2010 : AFE inhibited LPS induced ERK , JNK, and p38 phosphorylation
Gerilechaogetu et al., Anim Sci J 2009 : The signaling pathways leading to the activation of extracellular signal regulated kinase ( ERK ) by phorbol 12-myristate 13-acetate ( PMA ), formyl-methionylleucyl-phenylalanine ( fMLP ) and lipopolysaccharide (LPS) in chicken heterophils were examined ... These results indicate that the LPS induced phosphorylation of ERK in the chicken heterophils is mediated by PLC, PKC and intracellular calcium, and the PMA stimulated phosphorylation is dependent on intracellular calcium ion and PKC
Chao et al., J Agric Food Chem 2010 : At the same time, honokiol not only inhibited nitric oxide expression in LPS stimulated murine macrophages but also inhibited the LPS induced phosphorylation of ERK1/2 , JNK1/2, and p38
Tang et al., Am J Med Sci 2010 (Cell Transformation, Neoplastic...) : LPS increased the phosphorylation of ERK1/2 and P38 and activated NF-kappaB
Oh et al., Neurosci Lett 2010 (Inflammation) : We also showed that oleamide inhibited LPS induced phosphorylation of Akt, p38 MAPK, and ERK , activation of PI 3-kinase, and accumulation of reactive oxygen species ( ROS )
Huang et al., J Immunol 2010 : Blockage of LPS induced ERK , JNK, Akt, and NF-kappaB activation contributed to the inhibitory effect of quercetin on DCs
He et al., J Cell Biochem 2010 : The activation of TLR4 by LPS modulated the expression of TLRs, induced the phosphorylation of NF-kappaB, P38, and ERK42/44 , and up-regulated the gene expression of cytokines IL-8, IFN-alpha, IFN-beta, and TNF-alpha, suggesting EPCs expressed functional TLR4
Hsieh et al., Phytomedicine 2011 (Bone Resorption...) : On osteoclasts, icariin suppresses LPS mediated activation of the p38 and JNK ; while on the osteoblasts, icariin reduced the LPS induced activation of ERK1/2 and I-kappa-B-alpha ( I?Ba ), but increased the activation of p38
Peirce et al., PloS one 2010 : Moreover, LPS induced activation of the MAP kinases ERK and p38 was enhanced in cells over expressing Themis2 whereas the activation of JNK, IRF3 or NF-kappaB p65, was unaffected
Lu et al., Journal of neuroinflammation 2010 (Inflammation) : Resveratrol had no effect on LPS stimulated phosphorylation of ERK1/2 and p38 in microglia and astrocytes, but slightly inhibited LPS stimulated phosphorylation of JNK in astrocytes
Ta et al., Atherosclerosis 2010 : Results showed that 1nM of alogliptin inhibited ERK phosphorylation induced by lipopolysaccharide (LPS) , a ligand for toll-like receptor (TLR)4, by 91 %
Gorina et al., Glia 2011 : p38 exerted a strong influence on LPS induced gene expression by regulating the phosphorylation of Stat1 and the transcriptional activity of NF?B, while JNK regulated the Jak1/Stat1 pathway, and ERK1/2 controlled the expression of Egr-1 and influenced MyD88 dependent MMP-9 expression
Cho et al., Mol Immunol 2011 : However, IL-4 did not affect LPS induced phosphorylation of ERK and p38
Min et al., Int Immunopharmacol 2011 (Inflammation) : Withaferin A had no effect on LPS induced Akt and ERK phosphorylation, but phosphorylation of p38 and JNK was slightly decreased by withaferin A. Withaferin A significantly inhibited LPS induced STAT1 and STAT3 phosphorylation in a dose dependent manner
Terra et al., Free radical research 2011 (Inflammation...) : LPS induced ERK1/2 activation through phosphorylation, which was inhibited by all the compounds tested, the most active being epigallocatechin ( EG ), followed by epigallocatechin gallate ( EGCG ) and C1
Jang et al., Arch Oral Biol 2011 (Inflammation...) : bPN also inhibited the LPS stimulated activation of JNK and ERK signaling, and inhibited the LPS stimulated degradation of I ( K ) B in the RAW264.7 cells
Das et al., J Biol Chem 2011 (Substance Withdrawal Syndrome) : EMSA revealed a concurrent decrease in consensus binding to transcription factors NF?B, Activator Protein-1, and CCAAT/enhancer binding protein and Western blot analysis demonstrated a significant activation of LPS induced ERK1/2 phosphorylation ... Interestingly, although glucocorticoid treatment alone also modulated these transcription factors and ERK1/2 activation, the addition of glucocorticoids to MW samples resulted in a greater than additive reduction in the transcription factors and significant hyperactivation of LPS induced ERK1/2 phosphorylation
Kim et al., Evidence-based complementary and alternative medicine : eCAM 2012 : In addition, Myrrh inhibited LPS induced activation of c-jun NH ( 2 ) -terminal kinase ( JNK ) but not of extracellular signal regulated kinase ( ERK ), p38, and nuclear factor-?B
Watts et al., Am J Physiol Cell Physiol 2011 (MAP Kinase Signaling System...) : LPS induced a rapid ( < 15 min ) and sustained ( up to 60 min ) increase in ERK phosphorylation in microdissected MTALs that was blocked by PD98059
Küper et al., American journal of physiology. Renal physiology 2012 : In conclusion, these results propose that LPS mediates enhanced COX-2 expression in IMCD cells by 1 ) TLR4 mediated activation of the NF-?B signaling pathway, 2 ) TLR4 dependent release of TGF-a with subsequent activation of the EGFR and downstream MAPKs p38 and ERK1/2 , and 3 ) TLR4 mediated, EGFR independent activation of JNK that negatively regulates NF-?B activation
Shoeb et al., Free Radic Biol Med 2012 (Inflammation) : Furthermore, benfotiamine prevented the LPS induced phosphorylation of ERK1/2 and expression of transcription factors NF-?B and Egr-1
Guindi et al., Cell Immunol 2012 (MAP Kinase Signaling System) : LPS stimulation triggered ERK1/2 activation that was sustained in GM/DCs but not in IL-4/DCs
Park et al., PloS one 2011 : Capric acid had no effects on LPS induced activation of the NF-?B, JNK, ERK1/2 , and STAT1 pathways
Zhao et al., PloS one 2012 : The C-terminal region of p105 is necessary for LPS induced ERK activation and it has been suggested that ERK activity inhibits both IFN-ß and IL-12 p40 following LPS stimulation
Soromou et al., Molecules (Basel, Switzerland) 2012 : The data showed that 7-O-methylnaringenin could downregulate LPS induced levels of phosphorylation of ERK1/2 , JNK and I?Ba
Joo et al., Gut and liver 2012 : LPS induced phosphorylation of ERK1/2 , JNK, and p38 was inhibited by EGCG
Huang et al., PloS one 2012 (Edema...) : Inotilone also inhibited LPS induced ERK , JNK, and p38 phosphorylation
Fengyang et al., Inflammation 2012 (Inflammation...) : Western blot analysis showed that stevioside suppressed LPS induced NF-?B activation, I?Ba degradation, phosphorylation of ERK , JNK, and P38
Yang et al., Mol Cell Biol 2012 : The Nfkb1 ( SSAA ) mutation prevented the agonist induced release of TPL-2 from its inhibitor p105, which blocked activation of ERK by lipopolysaccharide (LPS) , tumor necrosis factor (TNF), CpG, tripalmitoyl-Cys-Ser-Lys ( Pam ( 3 ) CSK ), poly ( I · C ), flagellin, and R848
Peng et al., PloS one 2012 : We show here that DOK3 is a negative regulator of TLR signaling by limiting LPS induced ERK activation and cytokine responses in macrophages
Leow-Dyke et al., Journal of neuroinflammation 2012 (Immune System Diseases...) : In glial cultures, LPS induced activation of ERK1/2 , p38 and JNK ... In contrast, in neuronal cultures, LPS activated JNK but not ERK1/2 or p38, and the specific JNK inhibitor SP600125 significantly blocked LPS induced KC expression and release
Tang et al., Oncol Res 2012 (Colonic Neoplasms) : LPS increased phosphorylation of ERK1/2 and p38 and activated NF-kappaB
Han et al., Immunopharmacol Immunotoxicol 2013 (Inflammation...) : As a result, CPS inhibited proinflammatory cytokines, iNOS, and COX-2, which is attributed to the suppression of LPS induced ERK , JNK, and nuclear factor-?B ( NF-?B ) activation
Hong et al., BMC complementary and alternative medicine 2012 (Inflammation) : CWE blocked the LPS induced degradation of I?Ba as well as the activation of JNK, p38 and ERK1/2
Lee et al., J Cell Biochem 2013 : NaHS blocked nicotine and LPS induced activation of p38, ERK , MKP-1, PI3K, PKC, and PKC isoenzymes, and NF-?B
Ren et al., Zhonghua Gan Zang Bing Za Zhi 2012 : In addition, the phosphorylation levels of ERK and JNK were induced in macrophages at 15 min after LPS stimulation, while the phosphorylation level of p38 MAPK was induced at 1 h ; SB216763 pretreatment suppressed the LPS stimulated ERK , JNK and p38 phosphorylation in macrophages
Li et al., Cell Physiol Biochem 2012 (Acute Lung Injury...) : In freshly isolated alveolar macrophages from wild type and Ksr1-deficient mice, LPS increased ERK activation, nuclear translocation of NF?B and expression of inflammatory cytokines and chemokines in a similar pattern ... Inhibition of Src or Raf-1 blocked LPS induced ERK activation ... Taken together, these findings indicate that Ksr1 plays a dispensable role in LPS induced ERK activation in alveolar macrophages and does not contribute to the development of acute lung injury in the LPS model
Khan et al., J Ethnopharmacol 2013 (Edema...) : The LPS induced activation of p-JNK, p-p38, p-ERK , and p-Akt was significantly inhibited
Kim et al., Food Chem Toxicol 2013 (Inflammation) : DPEP inhibited LPS induced phosphorylation of ERK , JNK, and p38
Jeong et al., Food Chem Toxicol 2013 : In addition, PA inhibited LPS- or TNF-a stimulated ERK1/2 activation by decreasing phosphorylation of ERK1/2
Terazawa et al., Pharmacol Res 2013 : The compound 1 inhibited LPS stimulated ERK phosphorylation after LPS treatment
Slomiany et al., Inflammopharmacology 2013 : We show that ERK activation by the LPS leads to phosphorylation of the inhibitory ?B kinase-ß ( IKK-ß ) and cytosolic phospholipase A2 (cPLA2), and is reflected in the upsurge in NF-?B nuclear translocation, induction in COX-2 and iNOS expression, and up-regulation in cPLA2 activity
Wu et al., Bioorg Med Chem 2013 (Inflammation...) : Mechanistically, F35 and F36 dose-dependently prevented LPS induced NF-?B and ERK activation
Lee et al., Food Chem Toxicol 2013 : Further studies revealed that PL suppressed the production of tumor necrosis factor-a (TNF-a) or Interleukin (IL)-6 and activation of nuclear factor-?B ( NF-?B ) or extracellular regulated kinases (ERK) 1/2 by LPS
Chung et al., PloS one 2013 (Inflammation) : S100A12 reduced serum amyloid A-, but not LPS induced ERK1/2 phosphorylation to baseline
Uhde et al., Int Immunol 2013 : Furthermore, LPS stimulation led to high IL-10 production derived from CD83tg MZ B cells that reacted to LPS stimulation with enhanced ERK1/2 activation
Rao et al., PloS one 2013 : Similarly, low-dose LPS significantly inhibited TNF-a, IL-6, ATF4-CHOP pathway, NF-?B pathway, and ERK1/2 in high-dose LPS stimulated macrophages, whereas IL-10 and cytokine signaling ( SOCS ) -3 suppressor were induced
Gui et al., Mediators Inflamm 2013 (Sepsis) : Further studies showed that GW405833 inhibits LPS induced phosphorylation of ERK1/2 and STAT3 and blocks I ? B a degradation and NF- ? B p65 nuclear translocation in macrophages
Wan et al., J Endocrinol 2013 : DHT enhanced LPS induced p38MAPK, ERK1/2 , and nuclear factor ?B pathway activation, which may contribute to the elevated expression of UCN1
Wang et al., Dig Dis Sci 2013 (Carcinoma, Hepatocellular...) : LPS-TLR4 induced activation of ERK and JNK signaling promotes cell proliferation through regulating Bax translocation to mitochondria
Wu et al., Cell Res 2013 : Mlkl-deficient MEFs and macrophages were indistinguishable from wild-type cells in their ability to activate NF-?B, ERK , JNK, and p38 in response to TNF and lipopolysaccharides (LPS) , respectively
Han et al., Int Immunopharmacol 2013 : We found that sauchinone decreased the phosphorylation of p38 MAPK in lipopolysaccharide (LPS) stimulated murine bone marrow neutrophils, but not ERK1/2 and JNK
Sato et al., Biochem Biophys Res Commun 1995 : Western blots showed that DT-5461 suppressed the LPS induced tyrosine phosphorylation of p42mapk/ERK2
Geppert et al., Mol Med 1994 : Measurements of LPS induced MEK and ERK2 activity were undertaken in LPS-sensitive and LPS-insensitive cells ... In RAW 264.7 mouse macrophages, both ERK2 and MEK1 activity are induced by LPS treatment
Dziarski et al., J Infect Dis 1996 : sPGN- and LPS induced activation of ERK1 and ERK2, unlike PDB induced activation, was sensitive to inhibition by herbimycin A and insensitive to inhibition by increased intracellular cAMP
Durando et al., J Leukoc Biol 1998 : Pretreatment with PT inhibited basal and LPS stimulated , but not PMA stimulated ERK activation ... LPS pre-exposure resulted in a profound decrease in LPS stimulated activation of ERK , but did not affect PMA activation of ERK
Niiro et al., Biochem Biophys Res Commun 1998 : Interestingly, LPS induced phosphorylation and activation of ERK2 was significantly inhibited by IL-4 and IL-10, while that of p38 MAPK was inhibited by IL-10, but not IL-4
Hu et al., J Biol Chem 1998 : Moreover, the activation of ERK1 and ERK2 by LPS , but not by the phorbol ester, phorbol 12-myristate 13-acetate, is also blocked in RAW 264.7 cells by o-ATP pretreatment