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Roy et al., Surgery 1999 : We harvested adherent peritoneal macrophages harvested from wild-type ( WT ), heterozygous c-fos knockout ( Hetero KO ), or homozygous c-fos knockout ( Homo KO ) mice and investigated lipopolysaccharide (LPS) induced IL-12 p70 protein synthesis ( by enzyme linked immunosorbent assay ), IL-12 p35 and IL-12 p40 messenger RNA accumulation ( mRNA ) ( by reverse transcriptase-polymerase chain reaction ), and the transcription rate ( by nuclear runoff ) ... ( 2 ) LPS induces a significant increase in IL-12 p70 protein, IL-12 p40 mRNA, and the transcription rate in the Homo KO group compared with either the Hetero KO or WT groups
Huang et al., Infect Immun 1999 : In the absence of IL-10, B. abortus LPS induced strong IFN-gamma responses, but IL-12 p70 levels were still undetectable from BALB/c spleen cells
Mason et al., Alcohol Clin Exp Res 2000 : Ethanol pretreatment suppressed LPS induced IL-12 p70 and p40 protein production in blood and lung
Roy et al., Surgery 2000 : Overexpression of c-fos completely inhibited IL-4 primed LPS induced IL-12 p70 protein synthesis
Dai et al., Immunology 2001 : In this study, GL showed a dose dependent priming effect on lipopolysaccharide (LPS) induced IL-12 p40 and IL-12 p70 ( heterodimer of p40 and p35 ) protein production by peritoneal macrophages ( PM )
Haskó et al., Immunology 2001 : Sulphasalazine inhibited the LPS/IFN-gamma induced production of both interleukin-12 (IL-12) p40 and p70
Petro et al., Int Immunopharmacol 2002 : Both p70 and p40 are produced by macrophages in response to lipopolysaccharide (LPS) , IFN-gamma and/or CD40 ligation
Takakura et al., Inflamm Res 2002 (Disease Models, Animal...) : In the presence of LPS or anti-CD40 mAb, TNF-alpha and IL-12p70 release from macrophages of mutant mice was significantly higher than that from macrophages of wild-type mice
Prescott et al., Clin Exp Allergy 2003 (Hypersensitivity) : The capacity of circulating neonatal ( and maternal ) APC to produce IL-12 p70 in response to LPS ( and IFN-gamma ) stimulation was assessed in a group of 60 children with previously well characterized immune responses to allergens and atopic outcomes
Utsugi et al., J Immunol 2003 (MAP Kinase Signaling System) : Conversely, inhibition of JNK activation using SP600125 dose dependently enhanced both LPS induced IL-12 p40 production from THP-1 cells and p70 production from human monocytes
Martin et al., J Immunol 2003 (MAP Kinase Signaling System) : In the present study, the role of the phosphatidylinositol 3 kinase (PI3K)-Akt pathway in regulating P. gingivalis LPS induced production of IL-10, IL-12 p40, and IL-12 p70 by human monocytes was investigated
Morin et al., Clin Exp Immunol 2003 (Diabetes Mellitus) : As we shown previously, NOD BM-DC exhibit an enhanced capacity to produce IL-12p70 in response to lipopolysaccharide (LPS) and anti-CD40 stimulation compared to BM-DC from control mice
Begum et al., Infect Immun 2004 : ( iii ) Interleukin-23 (IL-23), rather than IL-12p70 , was induced by BCG-CWS, while interferon-inducible genes were induced only by LPS
Kim et al., Int Immunopharmacol 2004 : Resveratrol also significantly suppressed the ability of BM-DC to produce intracellular IL-12 p40/p70 and secretory IL-12 p70 in response to lipopolysaccharides (LPS) stimulation
Litjens et al., J Invest Dermatol 2004 (Psoriasis) : No association was observed between the various IL12B promoter genotypes and the LPS stimulated production of IL-12p70 or IL-12p40 by blood cells
Chen et al., J Immunol 2004 : PS liposomes inhibited the up-regulation of HLA-ABC, HLA-DR, CD80, CD86, CD40, and CD83, as well as the production of IL-12p70 by human DCs in response to LPS
Balic et al., Eur J Immunol 2004 (Strongylida Infections) : LPS induced high IL-12p70 levels, except in DC that had been pre incubated with NES
Traidl-Hoffmann et al., J Exp Med 2005 : Chemical analysis of Bet.-APE revealed the presence of phytoprostanes ( dinor isoprostanes ) with prostaglandin E ( 1 ) -, F ( 1 ) -, A ( 1 ) -, or B ( 1 ) -ring systems of which only E ( 1 ) -phytoprostanes dose dependently inhibited the LPS induced IL-12 p70 release and augmented the Th2 cell polarizing capacity of DC
Tournier et al., J Immunol 2005 : Furthermore, ET inhibits in vivo IL-12p70 and IFN-gamma secretion induced by LPS
Noone et al., J Gen Virol 2005 : HA selectively inhibits the release of LPS induced interleukin 12 (IL12) p70 , which is independent of IL10 secretion
Peng et al., Immunol Cell Biol 2006 (Autoimmune Diseases...) : IL10 and IL12B polymorphisms each influence IL-12p70 secretion by dendritic cells in response to LPS ... Here we show that polymorphisms not only of IL12B, but also in the IL10 promoter, influence IL-12p70 secretion by monocyte derived DC in response to LPS
Qian et al., Blood 2006 : Here, we report that unlike immature DCs, diffDCs secrete more interleukin 10 (IL-10) but little IL-12p70 in response to lipopolysaccharide (LPS) or other TLR agonists
Saito et al., Clinical and vaccine immunology : CVI 2006 : In response to LPS , peritoneal macrophages produced bioactive IL-12 p70 , a heterodimer ( p40/p35 ) of subunits, but macrophage lines such as J774.1 and RAW264.7 did not
Tsujimoto et al., Immunol Lett 2006 : LPS treated DCs could not produce IL-12p70 in response to subsequent both LPS- and CpG DNA-stimulation ... On the other hand, poly ( I:C ) -treated DCs retained to produce IL-12p70 by subsequent CpG DNA-stimulation, while subsequent LPS-stimulation did not induce IL-12p70 production
Aksoy et al., Blood 2007 : However, addition of exogenous IFNbeta failed to restore LPS induced IL-12p70 synthesis which was previously shown to be defective in neonatal moDCs
Hsu et al., J Allergy Clin Immunol 2007 : Le ( x ) and an isomer, Le ( y ), but not other isomers, inhibited the production of LPS induced IL-12p70 , associated with a significant reduction of nuclear NF-kappaB, in bone marrow derived dendritic cells from BALB/c mice, suggesting that Le ( x ) -induced suppression of IL-12p70 results in an enhanced T ( H ) 2 response
Gutermuth et al., J Allergy Clin Immunol 2007 : In vitro Bet-APEs and E ( 1 ) -phytoprostanes dose-dependently inhibited LPS induced IL-12p70 of DCs
Lin et al., J Leukoc Biol 2007 : Treatment of PlGF-DC or classical-DC with PlGF resulted in the down-regulation of CD80, CD86, CD83, CD40, and HLA-DR expression, and CD1a was increased, as well as the inhibition of IL-12 p70 , p40, IL-8, and TNF-alpha production in response to LPS stimulation
Casas et al., Scand J Immunol 2007 (Hypersensitivity) : Stimulation with birch and LPS resulted in an increased secretion of IL-12p70 in samples from healthy when compared with that in allergic individuals
Mandron et al., J Invest Dermatol 2008 (Dermatitis, Atopic...) : Monocytes from AD patients ( 15 adults with mostly severe disease and 15 children with mild to moderate disease ) exhibited an activated and tolerant state as supported by ( i ) secretion of large amounts of IL-6, IL-10, and tumor necrosis factor-alpha even in the absence of stimulation ; ( ii ) their inability to modulate neither HLA-DR and CD54 nor TLR2 and TLR4 expression after in vitro challenge with SEB ; ( iii ) inhibition of IL-12p70 secretion in response to LPS
Qi et al., Sci China C Life Sci 2000 : IFN-a also greatly promoted the LPS induced secretion of IL-12 p70 in MPSMs ... Taken together, the data suggest : ( i ) IFN-gamma/LPS could strongly induce the expression of IL-12 p40 and p35 mRNA ; both the expression levels were equal ; this phenomenon coincided with the high-level secretion of IL-12 p70 induced by IFN-gamma/LPS ; ( ii ) NF-kappaB signal pathway is essential for IFN-gamma/LPS to induce IL-12 mRNA expression ; ( iii ) by blocking the degradation of IkappaB, the PSI suppresses the IL-12 p40/p35 mRNA expression induced by LPS and IFN-gamma/LPS ; ( iv ) NF-kappaB signal may not be involved in the mechanism by which IFN-gamma enhanced the expression of the LPS induced IL-12 p40/p35 mRNA
Liu et al., Zhonghua Er Ke Za Zhi 2008 : ( 3 ) As compared with the control mice, concentration of IL-12p70 induced by LPS and IL-10 induced by BCG in vitro from spleen cells culture supernatant was noticeably elevated ( P < 0.05 ) in neonatal BCG treated BALB/c mice, but that of IL-6 did not change by LPS or BCG stimulation
Charoensap et al., Trans R Soc Trop Med Hyg 2008 (Melioidosis) : We also found that, although the LPS mutant could readily activate monocyte derived human DCs, it induced lower levels of IL-12p70 and IL-10 production than its wild-type counterpart ( P < 0.01 )
Gilles et al., J Immunol 2009 : Instead, PPE ( 1 ) inhibited the LPS induced production of IL-12 p70 by a mechanism involving the nuclear receptor PPAR-gamma
Belderbos et al., Clin Immunol 2009 : Skewed pattern of Toll-like receptor 4-mediated cytokine production in human neonatal blood : low LPS induced IL-12p70 and high IL-10 persist throughout the first month of life ... In contrast, TLR4 demonstrated a slower maturation, with low LPS induced IL-12p70 production and high IL-10 production up until the age of one month
Xuan et al., Cell Physiol Biochem 2010 : LPS increased the percentage of CD11c ( + ) CD86 ( + ), CD11c ( + ) MHCII ( + ), CD11c ( + ) CD40 ( + ) and CD11c ( + ) CD54 ( + ) cells and stimulated the release of IL-10, IL-12p70 and TNF-alpha
Marin-Esteban et al., J Immunother 2010 (Neoplasms) : LPS stimulation of DCs induced IL-10, IL-12p70 , TNFalpha and IL-1beta secretion, and taxol pretreatment modified this response by down regulating IL-1beta secretion whereas colchicine induced a proinflammatory cytokine profile with reduced IL-10 and increased IL-12p70 and TNFalpha secretion
Nguyen et al., PloS one 2010 : In response to LPS , production of TNF-alpha, IP-10 and IL-12p70 reached adult levels between 6-9 months of life
Xuan et al., Cell Physiol Biochem 2010 : Both LPS and GA stimulated the production of IL-6, IL-10, IL12p70 and TNFalpha in a p38- and/or ERK dependent manner
Kasai et al., J Med Invest 2011 (Bone Diseases, Metabolic) : In ex vivo cultures, raloxifene therapy inhibited LPS stimulated production of IL-1ß, IL-6, IL-12p40, IL-12p70 and TNF-a, but not PHA stimulated production of IL-4 and IFN-?
Michielsen et al., PloS one 2011 (Colorectal Neoplasms) : Pre-treatment of immature dendritic cells with VEGF inhibited LPS induced upregulation of CD80 and CD54, while CXCL1 inhibited HLA-DR. Interestingly, treatment of dendritic cells with CCL2, CXCL1, CXCL5 or VEGF significantly suppressed their ability to secrete IL-12p70 in response to LPS
Michielsen et al., Mol Cancer Ther 2012 (Colorectal Neoplasms) : TCM and BCM inhibited lipopolysaccharide (LPS) induced dendritic cell maturation and IL-12p70 secretion ( P < 0.0001 ), while increasing IL-10 secretion ( P = 0.0033 and 0.0220, respectively )
Matsui et al., Microbiol Immunol 2013 : In vitro experiments showed that PEG induced greater production of IL-12 p40 from LCs than did LPS, whereas LPS induced greater production of IL-12 p70 from LCs than did PEG
Zheng et al., PloS one 2013 : In this study, we demonstrate that heat killed C. albicans ( HKC ) strongly suppressed LPS induced IL-12p70 production in M2 macrophages ... Our results have indicated that C. albicans can suppress host inflammatory responses in mucosal skin by suppressing LPS induced IL-12p70 production
Sung et al., Biochem Biophys Res Commun 2013 : Lipopolysaccharide (LPS) induced expression of cell surface molecules ( CD80, CD86, and MHC class I/II ) and production of pro-inflammatory cytokines ( tumor necrosis factor-a, IL-1ß, IL-6, and IL-12p70 ) were inhibited by Pro B2, and this action was prevented by IRAK-M silencing